Literature DB >> 12527693

Protein C deficiency manifesting as an acute myocardial infarction and ischaemic stroke.

I Y Tiong1, M L Alkotob, S Ghaffari.   

Abstract

Protein C deficiency is a disorder in the coagulation cascade that results in predominantly venous thromboembolism. However, recent studies have implicated this disorder as a possible contributor to arterial thrombosis, especially myocardial infarction. There are six reported cases of myocardial infarction secondary to protein C deficiency in the literature. This is the first report of myocardial infarction and ischaemic stroke in the same patient as a manifestation of protein C deficiency. The investigation of hypercoagulable state is an essential component of the investigation of young patients with myocardial infarction.

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Year:  2003        PMID: 12527693      PMCID: PMC1767549          DOI: 10.1136/heart.89.2.e7

Source DB:  PubMed          Journal:  Heart        ISSN: 1355-6037            Impact factor:   5.994


  9 in total

1.  Acute myocardial infarction: a rare complication of protein C deficiency.

Authors:  A Sadiq; S Ahmed; A Karim; J Spivak; J Mattana
Journal:  Am J Med       Date:  2001-04-01       Impact factor: 4.965

2.  Recurring myocardial infarction in a 35 year old woman.

Authors:  I Bux-Gewehr; A Nacke; G E Feurle
Journal:  Heart       Date:  1999-03       Impact factor: 5.994

3.  Protein C deficiency and acute myocardial infarction in the third decade.

Authors:  S M Hacker; B D Williamson; S Lisco; J Kure; M Shea; B Pitt
Journal:  Am J Cardiol       Date:  1991-07-01       Impact factor: 2.778

4.  Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women.

Authors:  F R Rosendaal; D S Siscovick; S M Schwartz; R K Beverly; B M Psaty; W T Longstreth; T E Raghunathan; T D Koepsell; P H Reitsma
Journal:  Blood       Date:  1997-04-15       Impact factor: 22.113

5.  Prevalence of activated protein C resistance in acute myocardial infarction in Japan.

Authors:  K Hayashi; T Sone; J Kondoh; H Tsuboi; H Sassa; Y Numaguchi; Y Toki; K Okumura; T Ito; T Hayakawa
Journal:  Jpn Heart J       Date:  1997-11

6.  Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A.

Authors:  C J Doggen; V M Cats; R M Bertina; F R Rosendaal
Journal:  Circulation       Date:  1998-03-24       Impact factor: 29.690

7.  Absence of thrombosis in subjects with heterozygous protein C deficiency.

Authors:  J Miletich; L Sherman; G Broze
Journal:  N Engl J Med       Date:  1987-10-15       Impact factor: 91.245

8.  Inherited protein C deficiency and nonhemorrhagic arterial stroke in young adults.

Authors:  M Camerlingo; G Finazzi; L Casto; C Laffranchi; T Barbui; A Mamoli
Journal:  Neurology       Date:  1991-09       Impact factor: 9.910

9.  Congenital protein C deficiency and myocardial infarction:concomitant factor VII hyperactivity may play a role in the onset of arterial thrombosis.

Authors:  K Kario; T Matsuo; S Tai; S Sakamoto; T Yamada; T Miki; M Matsuo
Journal:  Thromb Res       Date:  1992-07-01       Impact factor: 3.944

  9 in total
  5 in total

1.  Recurrent cerebellar infarction associated with hereditary heterozygous protein C deficiency in a 35-year-old woman: A case report and genetic study on the pedigree.

Authors:  Pingping Li; Chao Qin
Journal:  Exp Ther Med       Date:  2018-07-25       Impact factor: 2.447

2.  Role of investigating thrombophilic disorders in young stroke.

Authors:  Kay W P Ng; Pei K Loh; Vijay K Sharma
Journal:  Stroke Res Treat       Date:  2011-02-08

3.  Combined effects of thrombosis pathway gene variants predict cardiovascular events.

Authors:  Kirsi Auro; Mervi Alanne; Kati Kristiansson; Kaisa Silander; Kari Kuulasmaa; Veikko Salomaa; Leena Peltonen; Markus Perola
Journal:  PLoS Genet       Date:  2007-06-07       Impact factor: 5.917

Review 4.  Protein C Deficiency as a Risk Factor for Stroke in Young Adults: A Review.

Authors:  Zainab Majid; Faryal Tahir; Jawad Ahmed; Taha Bin Arif; Anwarul Haq
Journal:  Cureus       Date:  2020-03-30

5.  Cerebral Infarction Followed by Myocardial Infarction in a Young Adult with Protein C and S Deficiency.

Authors:  Faryal Tahir; Zainab Majid; Taha Bin Arif; Jawad Ahmed
Journal:  Cureus       Date:  2020-01-15
  5 in total

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