Literature DB >> 12527228

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.

Jenefer M Blackwell1, Susan Searle, Hiba Mohamed, Jacqueline K White.   

Abstract

Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages; (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1; and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms.

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Year:  2003        PMID： 12527228     DOI： 10.1016/s0165-2478(02)00231-6

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  47 in total

1.  Association of polymorphisms in the Chr18q11.2 locus with tuberculosis in Chinese population.

Authors:  Xingyan Wang; Nelson Leung-Sang Tang; Chi Chiu Leung; Kai Man Kam; Wing Wai Yew; Cheuk Ming Tam; Chiu Yeung Chan
Journal:  Hum Genet       Date:  2013-03-03       Impact factor: 4.132

2.  A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production.

Authors:  M Carolina Pilonieta; Toni A Nagy; Dana R Jorgensen; Corrella S Detweiler
Journal:  Mol Microbiol       Date:  2012-03-09       Impact factor: 3.501

3.  Evidence that highly conserved residues of transmembrane segment 6 of Escherichia coli MntH are important for transport activity.

Authors:  Heather A H Haemig; Patrick J Moen; Robert J Brooker
Journal:  Biochemistry       Date:  2010-06-08       Impact factor: 3.162

4.  Solute carrier family 11 member A1 gene polymorphisms in reactive arthritis.

Authors:  Yi-Jing Chen; Chia-Hui Lin; Tsan-Teng Ou; Cheng-Chin Wu; Wen-Chan Tsai; Hong-Wen Liu; Jeng-Hsien Yen
Journal:  J Clin Immunol       Date:  2007-01-09       Impact factor: 8.317

5.  Solute carrier protein family 11 member 1 (Slc11a1) activation efficiently inhibits Leishmania donovani survival in host macrophages.

Authors:  Nisha Singh; Mallikarjuna Rao Gedda; Neeraj Tiwari; Suya P Singh; Surabhi Bajpai; Rakesh K Singh
Journal:  J Parasit Dis       Date:  2016-11-12

Review 6.  Manipulation of iron to determine survival: competition between host and pathogen.

Authors:  Nihay Laham; Rachel Ehrlich
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

7.  A major susceptibility locus on chromosome 22q12 plays a critical role in the control of kala-azar.

Authors:  Bruno Bucheton; Laurent Abel; Sayda El-Safi; Musa M Kheir; Sylvana Pavek; Arnaud Lemainque; Alain J Dessein
Journal:  Am J Hum Genet       Date:  2003-10-13       Impact factor: 11.025

Review 8.  Genetics and visceral leishmaniasis: of mice and man.

Authors:  J M Blackwell; M Fakiola; M E Ibrahim; S E Jamieson; S B Jeronimo; E N Miller; A Mishra; H S Mohamed; C S Peacock; M Raju; S Sundar; M E Wilson
Journal:  Parasite Immunol       Date:  2009-05       Impact factor: 2.280

9.  Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.

Authors:  Hariklia Eleftherohorinou; Victoria Wright; Clive Hoggart; Anna-Liisa Hartikainen; Marjo-Riitta Jarvelin; David Balding; Lachlan Coin; Michael Levin
Journal:  PLoS One       Date:  2009-11-30       Impact factor: 3.240

10.  Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus.

Authors:  Daniela Paccagnini; Lee Sieswerda; Valentina Rosu; Speranza Masala; Adolfo Pacifico; Maria Gazouli; John Ikonomopoulos; Niyaz Ahmed; Stefania Zanetti; Leonardo A Sechi
Journal:  PLoS One       Date:  2009-09-21       Impact factor: 3.240
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