| Literature DB >> 12527215 |
Abstract
Follicular B helper T (T(FH)) cells make up a CD4(+) memory T cell subset with unique migration properties, defined by the expression of the chemokine receptor CXCR5 and responsiveness to the CXCR5-selective chemokine BCA-1, which is produced in B cell follicles. The generation of T(FH) cells is closely associated with initiation of adaptive immunity. Here, we discuss the relationship of T(FH) cells with those T cells characterized by an inherent secondary lymphoid tissue homing program. Special emphasis is placed on the potential involvement of T(FH) cells in the humoral immune response within B cell follicles, as well as the differentiation potential of these non-polarized cells.Entities:
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Year: 2003 PMID: 12527215 DOI: 10.1016/s0165-2478(02)00233-x
Source DB: PubMed Journal: Immunol Lett ISSN: 0165-2478 Impact factor: 3.685