Literature DB >> 12526835

Synthesis of monomethylated dioscin derivatives and their antitumor activities.

Ming Li1, Xiuwen Han, Biao Yu.   

Abstract

All possible eight monomethylated dioscin derivatives (1-8) were synthesized. Their inhibitory activities against P388 and A-549 cells were determined, and the results indicate that six of the eight hydroxyls of dioscin are the 'key polar groupings' for tumor inhibitory activities.

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Year:  2003        PMID： 12526835     DOI： 10.1016/s0008-6215(02)00443-3

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  4 in total

Review 1.  Herbal medicines and nonalcoholic fatty liver disease.

Authors:  Hong Yao; Yu-Jie Qiao; Ya-Li Zhao; Xu-Feng Tao; Li-Na Xu; Lian-Hong Yin; Yan Qi; Jin-Yong Peng
Journal:  World J Gastroenterol       Date:  2016-08-14       Impact factor: 5.742

2.  Potent effects of dioscin against obesity in mice.

Authors:  Min Liu; Lina Xu; Lianhong Yin; Yan Qi; Youwei Xu; Xu Han; Yanyan Zhao; Huijun Sun; Jihong Yao; Yuan Lin; Kexin Liu; Jinyong Peng
Journal:  Sci Rep       Date:  2015-01-22       Impact factor: 4.379

3.  Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and Oxidative Stress.

Authors:  Hong Yao; Youwei Xu; Lianhong Yin; Xufeng Tao; Lina Xu; Yan Qi; Xu Han; Pengyuan Sun; Kexin Liu; Jinyong Peng
Journal:  Front Pharmacol       Date:  2017-03-08       Impact factor: 5.810

Review 4.  Synthesis, Modification and Biological Activity of Diosgenyl β-d-Glycosaminosides: An Overview.

Authors:  Daria Grzywacz; Beata Liberek; Henryk Myszka
Journal:  Molecules       Date:  2020-11-20       Impact factor: 4.411
  4 in total

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