Literature DB >> 12526767

Pathways to Parkinsonism.

Mark R Cookson1.   

Abstract

A novel gene for Parkinson's disease (PD), DJ-1, has been identified that encodes a multifunctional product with several known protein-protein interactions and effects on gene expression. Here, I outline how it is possible to construct hypotheses that place DJ-1 in different relationships to the other known PD genes, alpha-synuclein and parkin. The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD.

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Year:  2003        PMID： 12526767     DOI： 10.1016/s0896-6273(02)01166-2

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  25 in total

1.  Crystallizing ideas about Parkinson's disease.

Authors:  Mark R Cookson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-28       Impact factor: 11.205

Review 2.  The role of cysteine oxidation in DJ-1 function and dysfunction.

Authors:  Mark A Wilson
Journal:  Antioxid Redox Signal       Date:  2011-01-14       Impact factor: 8.401

3.  Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.

Authors:  Eunsung Junn; Hiroyuki Taniguchi; Byeong Seon Jeong; Xin Zhao; Hidenori Ichijo; M Maral Mouradian
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-27       Impact factor: 11.205

Review 4.  Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention.

Authors:  Malú G Tansey; Melissa K McCoy; Tamy C Frank-Cannon
Journal:  Exp Neurol       Date:  2007-07-17       Impact factor: 5.330

Review 5.  Neurodegeneration and neuroprotection in Parkinson disease.

Authors:  Stanley Fahn; David Sulzer
Journal:  NeuroRx       Date:  2004-01

6.  Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.

Authors:  Guido Krebiehl; Sabine Ruckerbauer; Lena F Burbulla; Nicole Kieper; Brigitte Maurer; Jens Waak; Hartwig Wolburg; Zemfira Gizatullina; Frank N Gellerich; Dirk Woitalla; Olaf Riess; Philipp J Kahle; Tassula Proikas-Cezanne; Rejko Krüger
Journal:  PLoS One       Date:  2010-02-23       Impact factor: 3.240

Review 7.  Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease.

Authors:  Ashok N Hegde; Sudarshan C Upadhya
Journal:  Biochim Biophys Acta       Date:  2010-08-03

8.  Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.

Authors:  Christophe Lo Bianco; Bernard L Schneider; Matthias Bauer; Ali Sajadi; Alexis Brice; Takeshi Iwatsubo; Patrick Aebischer
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-02       Impact factor: 11.205

9.  The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.

Authors:  Mark A Wilson; Jennifer L Collins; Yaacov Hod; Dagmar Ringe; Gregory A Petsko
Journal:  Proc Natl Acad Sci U S A       Date:  2003-07-10       Impact factor: 11.205

10.  Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S.

Authors:  Min Liu; Samantha A Bender; Gregory D Cuny; Woody Sherman; Marcie Glicksman; Soumya S Ray
Journal:  Biochemistry       Date:  2013-03-01       Impact factor: 3.162
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