Literature DB >> 1252659

Metabolism of phenylethylamine in rat isolated perfused lung: evidence for monoamine oxidase 'type B' in lung.

Y S Bakhle, M B Youdim.   

Abstract

Phenylethylamine is inactivated in a single passage through rat lung tissue by a process of uptake and deamination by a monoamine oxidase 'type B'. This enzyme is particularly susceptible to inhibition by deprenil and less sensitive to clorgyline. The monoamine oxidase of the lung, like that of other rat tissues, can be differentiated into 'type A' and 'type B' which appear to operate independently in the organized tissue.

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Year:  1976        PMID: 1252659      PMCID: PMC1666762          DOI: 10.1111/j.1476-5381.1976.tb06967.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN: 0007-1188            Impact factor:   8.739


  16 in total

1.  The influence of tissue environment on the rates of metabolic processes and the properties of enzymes.

Authors:  M B Youdim; H F Woods
Journal:  Biochem Pharmacol       Date:  1975-02-01       Impact factor: 5.858

2.  Amine competition for oxidation by rat liver mitochondrial monoamine oxidase.

Authors:  M D Houslay; K F Tipton
Journal:  Biochem Pharmacol       Date:  1975-03-01       Impact factor: 5.858

Review 3.  Pharmacokinetic function of the pulmonary circulation.

Authors:  Y S Bakhle; J R Vane
Journal:  Physiol Rev       Date:  1974-10       Impact factor: 37.312

4.  Site and mechanism of uptake of 3H--norepinephrine by isolated perfused rat lungs.

Authors:  T E Nicholas; J M Strum; L S Angelo; A F Junod
Journal:  Circ Res       Date:  1974-11       Impact factor: 17.367

5.  Beta-phenylethylamine: a specific substrate for type B monoamine oxidase of brain.

Authors:  H Y Yang; N H Neff
Journal:  J Pharmacol Exp Ther       Date:  1973-11       Impact factor: 4.030

6.  Pharmacological analysis of norepinephrine and 5-hydroxytryptamine removal from the pulmonary circulation: differentiation of uptake sites for each amine.

Authors:  Y Iwasawa; C N Gillis
Journal:  J Pharmacol Exp Ther       Date:  1974-02       Impact factor: 4.030

7.  Some puzzling pharmacological effects of monoamine oxidase inhibitors.

Authors:  J Knoll; K Magyar
Journal:  Adv Biochem Psychopharmacol       Date:  1972

8.  The estimation of monoamine oxidase using 14C-labelled substrates.

Authors:  J Southgate; G G Collins
Journal:  Biochem Pharmacol       Date:  1969-09       Impact factor: 5.858

9.  The uptake and disposition of dl-norepinephrine in perfused rat lung.

Authors:  J Hughes; C N Gillis; F E Bloom
Journal:  J Pharmacol Exp Ther       Date:  1969-10       Impact factor: 4.030

10.  Removal of 5-hydroxytryptamine in the pulmonary circulation of rat isolated lungs.

Authors:  V A Alabaster; Y S Bakhle
Journal:  Br J Pharmacol       Date:  1970-11       Impact factor: 8.739

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  8 in total

1.  Selectivity of clorgyline and pargyline as inhibitors of monoamine oxidases A and B in vivo in man.

Authors:  D L Murphy; S Lipper; S Slater; D Shiling
Journal:  Psychopharmacology (Berl)       Date:  1979-04-11       Impact factor: 4.530

2.  Some characteristics of the metabolism of beta-phenylethylamine in rat isolated lung [proceedings].

Authors:  Y S Bakhle
Journal:  Br J Pharmacol       Date:  1977-06       Impact factor: 8.739

Review 3.  Physiological and pathological changes in tissue monoamine oxidase activity.

Authors:  M B Youdim; M Holzbauer
Journal:  J Neural Transm       Date:  1976       Impact factor: 3.575

Review 4.  Role of the lung in total body clearance of circulating drugs.

Authors:  R A Roth; D A Wiersma
Journal:  Clin Pharmacokinet       Date:  1979 Sep-Oct       Impact factor: 6.447

5.  End-plate voltage noise during prolonged application of acetylcholine in cat tenuissimus muscle [proceedings].

Authors:  D Wray
Journal:  J Physiol       Date:  1978-05       Impact factor: 5.182

6.  The morphology of Group Ib muscle afferent fibre collaterals [proceedings].

Authors:  A G Brown; R E Fyffe
Journal:  J Physiol       Date:  1978-04       Impact factor: 5.182

7.  The metabolism of 5-hydroxytryptamine and beta-phenylethylamine in perfused rat lung and in vitro.

Authors:  Y S Bakhle; M B Youdim
Journal:  Br J Pharmacol       Date:  1979-01       Impact factor: 8.739

8.  The fate of biogenic monoamines in perfused rabbit lung.

Authors:  C N Gillis; J A Roth
Journal:  Br J Pharmacol       Date:  1977-04       Impact factor: 8.739

  8 in total

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