| Literature DB >> 12525734 |
J Arenas1, M A Fernández-Moreno, J A Molina, V Fernández, P del Hoyo, Y Campos, P Calvo, M A Martín, A García, T Moreno, A Martínez-Salio, B Börnstein, F Bermejo, A Cabello, R Garesse.
Abstract
The authors describe a patient who presented with myoglobinuria after starting cerivastatin-gemfibrozil therapy. Muscle histochemistry revealed ragged-red fibers and cytochrome c oxidase negative (COX) fibers, and biochemistry showed a defect of COX activity. Immunoblot analysis showed a 60% reduction of COX I and COX II polypeptides. Cerivastatin myotoxicity might be related to a depletion of essential metabolites needed to anchor COX subunit I to mitochondrial membrane.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12525734 DOI： 10.1212/01.wnl.0000042050.85041.fb
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910