| Literature DB >> 12525679 |
Lucio G Costa1, Toby B Cole, Gail P Jarvik, Clement E Furlong.
Abstract
This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.Entities:
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Year: 2001 PMID： 12525679 DOI： 10.1146/annurev.med.54.101601.152421
Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739