PURPOSE: To determine a gene locus for a family with a dominantly inherited vestibulocerebellar disorder characterised by early onset, but not congenital nystagmus. DESIGN: Observational and experimental study. METHODS: We carried out a phenotypic study of a unique four generation family with nystagmus. We performed genetic linkage studies including a genome wide search. RESULTS: Affected family members developed vestibulocerebellar type nystagmus in the first two years of life. A higher incidence of strabismus was noted in affected members. Haplotype construction and analysis of recombination events linked the disorder to a locus (NYS4) on chromosome 13q31-q33 with a lod score of 6.322 at theta=0 for D13S159 and narrowed the region to a 13.8 cM region between markers D13S1300 and D13S158. CONCLUSIONS: This study suggests that the early onset acquired nystagmus seen in this family is caused by a single gene defect. Identification of the gene may hold the key to understanding pathways for early eye stabilisation and strabismus.
PURPOSE: To determine a gene locus for a family with a dominantly inherited vestibulocerebellar disorder characterised by early onset, but not congenital nystagmus. DESIGN: Observational and experimental study. METHODS: We carried out a phenotypic study of a unique four generation family with nystagmus. We performed genetic linkage studies including a genome wide search. RESULTS: Affected family members developed vestibulocerebellar type nystagmus in the first two years of life. A higher incidence of strabismus was noted in affected members. Haplotype construction and analysis of recombination events linked the disorder to a locus (NYS4) on chromosome 13q31-q33 with a lod score of 6.322 at theta=0 for D13S159 and narrowed the region to a 13.8 cM region between markers D13S1300 and D13S158. CONCLUSIONS: This study suggests that the early onset acquired nystagmus seen in this family is caused by a single gene defect. Identification of the gene may hold the key to understanding pathways for early eye stabilisation and strabismus.
Authors: Anna Hackett; Patrick S Tarpey; Andrea Licata; James Cox; Annabel Whibley; Jackie Boyle; Carolyn Rogers; John Grigg; Michael Partington; Roger E Stevenson; John Tolmie; John Rw Yates; Gillian Turner; Meredith Wilson; Andrew P Futreal; Mark Corbett; Marie Shaw; Jozef Gecz; F Lucy Raymond; Michael R Stratton; Charles E Schwartz; Fatima E Abidi Journal: Eur J Hum Genet Date: 2009-12-23 Impact factor: 4.246
Authors: Mervyn G Thomas; Moira Crosier; Susan Lindsay; Anil Kumar; Shery Thomas; Masasuke Araki; Chris J Talbot; Rebecca J McLean; Mylvaganam Surendran; Katie Taylor; Bart P Leroy; Anthony T Moore; David G Hunter; Richard W Hertle; Patrick Tarpey; Andrea Langmann; Susanne Lindner; Martina Brandner; Irene Gottlob Journal: Brain Date: 2011-02-08 Impact factor: 13.501
Authors: Anja K Mayer; Muhammad Mahajnah; Mervyn G Thomas; Yuval Cohen; Adib Habib; Martin Schulze; Gail D E Maconachie; Basamat AlMoallem; Elfride De Baere; Birgit Lorenz; Elias I Traboulsi; Susanne Kohl; Abdussalam Azem; Peter Bauer; Irene Gottlob; Rajech Sharkia; Bernd Wissinger Journal: Brain Date: 2019-06-01 Impact factor: 13.501