Literature DB >> 12525389

Transforming growth factor beta 1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor alpha from bovine cartilage.

W Hui1, T Cawston, A D Rowan.   

Abstract

Oncostatin M (OSM) in combination with tumour necrosis factor alpha (TNF alpha) promotes marked collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases and could be prevented by transforming growth factor beta 1 (TGF beta 1) or insulin-like growth factor 1. Both growth factors reduced the expression and secretion of collagenase enzymes, and TGF beta 1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against OSM+TNF alpha induced destruction.

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Year:  2003        PMID： 12525389      PMCID： PMC1754447          DOI： 10.1136/ard.62.2.172

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  14 in total

1.  Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.

Authors:  W Hui; H E Barksby; D A Young; T E Cawston; N McKie; A D Rowan
Journal:  Ann Rheum Dis       Date:  2005-05-05       Impact factor: 19.103

2.  Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.

Authors:  Gary J Litherland; Martina S Elias; Wang Hui; Christopher D Macdonald; Jonathon B Catterall; Matt J Barter; Matthew J Farren; Matthew Jefferson; Andrew D Rowan
Journal:  J Biol Chem       Date:  2010-05-12       Impact factor: 5.157

3.  Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads.

Authors:  S Chubinskaya; A Hakimiyan; C Pacione; A Yanke; L Rappoport; T Aigner; D C Rueger; R F Loeser
Journal:  Osteoarthritis Cartilage       Date:  2006-11-27       Impact factor: 6.576

4.  Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network.

Authors:  Anna Asanbaeva; Koichi Masuda; Eugene J-M A Thonar; Stephen M Klisch; Robert L Sah
Journal:  Biomech Model Mechanobiol       Date:  2007-08-29

5.  Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.

Authors:  Andrew D Rowan; Wang Hui; Tim E Cawston; Carl D Richards
Journal:  Am J Pathol       Date:  2003-06       Impact factor: 4.307

6.  Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction.

Authors:  Dana M Cairns; Tomoya Uchimura; Heenam Kwon; Philip G Lee; Christopher R Seufert; Elizabeth Matzkin; Li Zeng
Journal:  Biochem Biophys Res Commun       Date:  2009-12-31       Impact factor: 3.575

7.  Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.

Authors:  Chun Ming Chan; Christopher D Macdonald; Gary J Litherland; David J Wilkinson; Andrew Skelton; G Nicholas Europe-Finner; Andrew D Rowan
Journal:  J Biol Chem       Date:  2016-12-12       Impact factor: 5.157

8.  Developmental mechanisms in articular cartilage degradation in osteoarthritis.

Authors:  Elena V Tchetina
Journal:  Arthritis       Date:  2010-12-29

9.  A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL.

Authors:  Wang Hui; Tim E Cawston; Carl D Richards; Andrew D Rowan
Journal:  Arthritis Res Ther       Date:  2004-11-10       Impact factor: 5.156

Review 10.  Cells of the synovium in rheumatoid arthritis. Chondrocytes.

Authors:  Miguel Otero; Mary B Goldring
Journal:  Arthritis Res Ther       Date:  2007       Impact factor: 5.156
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