Literature DB >> 1252495

Metabolism of [14C]arachidonic acid by human platelets.

T K Bills, J B Smith, M J Silver.   

Abstract

A time dependent incorporation of [1-14C] arachidonic acid into platelet phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, and phosphatidylserine was observed in platelet-rich plasma. When platelets, so labelled, were washed and treated with thrombin, there was a major decrease in the radioactivity of phosphatidylcholine and phosphatidylinositol. This decrease was accounted for by the appearance of several previously identified (Hamberg and Samuelsson (1974) Proc. Natl. Acad. Sci. U.S. 71, 3400) 14C-labelled oxygenated products of arachidonic acid.

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Year:  1976        PMID: 1252495     DOI: 10.1016/0005-2760(76)90198-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  67 in total

1.  Rapid inactivation of cyclooxygenase activity after stimulation of intact platelets.

Authors:  E G Lapetina; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

2.  Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products.

Authors:  E G Lapetina; K A Chandrabose; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

3.  Increased arachidonic acid incorporation into platelet phospholipids in type 2 (non-insulin-dependent) diabetes.

Authors:  R Takahashi; I Morita; Y Saito; H Ito; S Murota
Journal:  Diabetologia       Date:  1984-02       Impact factor: 10.122

4.  Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid.

Authors:  J P Brammer; M H Maguire
Journal:  Br J Pharmacol       Date:  1984-05       Impact factor: 8.739

5.  Arachidonic acid metabolites, hypertension and arteriosclerosis.

Authors:  P C Weber; W Siess; B Scherer; E Held; H Witzgall; R Lorenz
Journal:  Klin Wochenschr       Date:  1982-05-17

6.  Neutrophil aggregation and degranulation. Effect of arachidonic acid.

Authors:  J T O'Flaherty; H J Showell; E L Becker; P A Ward
Journal:  Am J Pathol       Date:  1979-05       Impact factor: 4.307

7.  Marked increase of human platelet phospholipase A2 activity in vitro and demonstration of an endogenous inhibitor.

Authors:  L R Ballou; W Y Cheung
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

8.  Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin.

Authors:  J D Vickers; R L Kinlough-Rathbone; J F Mustard
Journal:  Biochem J       Date:  1984-04-01       Impact factor: 3.857

9.  Relationship of prostaglandin secretion by rabbit alveolar macrophages to phagocytosis and lysosomal enzyme release.

Authors:  W Hsueh; C Kuhn; P Needleman
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

10.  Regulation of prostaglandin synthesis and of the selective release of lysosomal hydrolases by mouse peritoneal macrophages.

Authors:  R J Bonney; P D Wightman; P Davies; S J Sadowski; F A Kuehl; J L Humes
Journal:  Biochem J       Date:  1978-11-15       Impact factor: 3.857

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