| Literature DB >> 12524203 |
Andrew R Reynolds1, S Moein Moghimi, Kairbaan Hodivala-Dilke.
Abstract
The alpha(v)beta(3) integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of alpha(v)beta(3)-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.Entities:
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Year: 2003 PMID: 12524203 DOI: 10.1016/s1471-4914(02)00004-7
Source DB: PubMed Journal: Trends Mol Med ISSN: 1471-4914 Impact factor: 11.951