STUDY OBJECTIVE: To ascertain the relationship between warfarin therapy and subsequent hip fracture in a large elderly population. DESIGN: Retrospective, population-based cohort study. SETTING: Population-based health care administrative databases for Ontario, Canada. PATIENTS: Elderly patients receiving warfarin (52,701 patients), thyroid replacement therapy (40,555), an oral corticosteroid (43,915), or a proton pump inhibitor (60,383). The proton pump inhibitor group served as controls. MEASUREMENTS AND MAIN RESULTS: The association between warfarin therapy and subsequent hospitalization for hip fracture in elderly patients was examined by researching administrative data from January 1, 1994-March 31, 1999, for the elderly population of Ontario. Relative to patients receiving proton pump inhibitors, patients receiving warfarin (adjusted risk ratio [aRR] 0.94, 95% confidence interval [CI] 0.81-1.09) or thyroid replacement therapy (aRR 1.02, 95% Cl 0.89-1.18) incurred similar risks of hip fracture. As expected, patients receiving oral corticosteroids incurred an increased risk (aRR 1.44, 95% CI 1.21-1.70) relative to patients receiving proton pump inhibitors. CONCLUSION: Warfarin was not associated with increased risk of hip fracture.
STUDY OBJECTIVE: To ascertain the relationship between warfarin therapy and subsequent hip fracture in a large elderly population. DESIGN: Retrospective, population-based cohort study. SETTING: Population-based health care administrative databases for Ontario, Canada. PATIENTS: Elderly patients receiving warfarin (52,701 patients), thyroid replacement therapy (40,555), an oral corticosteroid (43,915), or a proton pump inhibitor (60,383). The proton pump inhibitor group served as controls. MEASUREMENTS AND MAIN RESULTS: The association between warfarin therapy and subsequent hospitalization for hip fracture in elderly patients was examined by researching administrative data from January 1, 1994-March 31, 1999, for the elderly population of Ontario. Relative to patients receiving proton pump inhibitors, patients receiving warfarin (adjusted risk ratio [aRR] 0.94, 95% confidence interval [CI] 0.81-1.09) or thyroid replacement therapy (aRR 1.02, 95% Cl 0.89-1.18) incurred similar risks of hip fracture. As expected, patients receiving oral corticosteroids incurred an increased risk (aRR 1.44, 95% CI 1.21-1.70) relative to patients receiving proton pump inhibitors. CONCLUSION:Warfarin was not associated with increased risk of hip fracture.
Authors: M Fusaro; G Crepaldi; S Maggi; F Galli; A D'Angelo; L Calò; S Giannini; D Miozzo; M Gallieni Journal: J Endocrinol Invest Date: 2010-11-16 Impact factor: 4.256
Authors: M L Avila; E Pullenayegum; S Williams; A Shammas; J Stimec; E Sochett; K Marr; L R Brandão Journal: Osteoporos Int Date: 2015-11-16 Impact factor: 4.507