Literature DB >> 1252023

Hydroxocobalamin therapy of cyanide intoxication in guinea pigs.

M A Posner, R E Tobey, H McElroy.   

Abstract

The efficacy of hydroxocobalamin (vitamin B12a) as a specific, nontoxic antidote in acute cyanide poisoning was tested. Guinea pigs receiving lethal intravenous NaCN injections were treated with either vitamin B12a or saline solution. There was a statistically significant antidotal effect of the vitamin. No toxic effect was observed with large doses of the vitamin.

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Year:  1976        PMID: 1252023     DOI: 10.1097/00000542-197602000-00017

Source DB:  PubMed          Journal:  Anesthesiology        ISSN: 0003-3022            Impact factor:   7.892


  2 in total

1.  The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning.

Authors:  Adriano Chan; Daune L Crankshaw; Alexandre Monteil; Steven E Patterson; Herbert T Nagasawa; Jackie E Briggs; Joseph A Kozocas; Sari B Mahon; Matthew Brenner; Renate B Pilz; Timothy D Bigby; Gerry R Boss
Journal:  Clin Toxicol (Phila)       Date:  2011-06       Impact factor: 4.467

2.  Cyanide poisoning after bitter almond ingestion.

Authors:  T A Shragg; T E Albertson; C J Fisher
Journal:  West J Med       Date:  1982-01
  2 in total

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