Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Polymorphisms and the antiviral property of porcine Mx1 protein.

Literature DB >> 12520098

Polymorphisms and the antiviral property of porcine Mx1 protein.

Atsushi Asano¹, Jae Hong Ko, Takeya Morozumi, Noriyuki Hamashima, Tomomasa Watanabe.

Abstract

We determined the cDNA sequences of the type I interferon-inducible proteins, pig Mx1 from PK(15) and LLC-PK1 cells, and compared the antiviral activities of both Mx proteins, including Mx1 polymorphisms against vesicular stomatitis virus (VSV). Mx1 cDNA derived from PK(15) cells had an 11 bp-deletion in the 3' end of the coding region, and was estimated to encode 8 amino acid substitutions and a 23 amino acid extension compared to that from LLC-PK1 cells. VSV replication was inhibited in the 3T3 cells expressing Mx1 mRNA after the cDNA was transfected. However, the efficiency of this inhibition was not different between the cells expressing Mx1 mRNA from both PK and LLC. These results indicate that pig Mx1 protein confers resistance to VSV.

Entities: Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12520098 DOI： 10.1292/jvms.64.1085

Source DB: PubMed Journal: J Vet Med Sci ISSN： 0916-7250 Impact factor: 1.267

Keyword Cloud
Cited

18 in total

1. The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus.

Authors: Susan L Brockmeier; Crystal L Loving; Eric A Nelson; Laura C Miller; Tracy L Nicholson; Karen B Register; Marvin J Grubman; Douglas E Brough; Marcus E Kehrli
Journal: Clin Vaccine Immunol Date: 2012-02-01

2. Association of multi-pathogenic infections with BAT2, CXCL12, Mx1 and EHMT2 variations in pigs.

Authors: S J Wang; W J Liu; L G Yang; H B Liu; C A Sargent; N A Affara; S J Zhang
Journal: Mol Biol Rep Date: 2012-04-25 Impact factor: 2.316

Review 3. Mx proteins: antiviral gatekeepers that restrain the uninvited.

Authors: Judith Verhelst; Paco Hulpiau; Xavier Saelens
Journal: Microbiol Mol Biol Rev Date: 2013-12 Impact factor: 11.056

4. "Self" and "nonself" manipulation of interferon defense during persistent infection: bovine viral diarrhea virus resists alpha/beta interferon without blocking antiviral activity against unrelated viruses replicating in its host cells.

Authors: Matthias Schweizer; Philippe Mätzener; Gabriela Pfaffen; Hanspeter Stalder; Ernst Peterhans
Journal: J Virol Date: 2006-07 Impact factor: 5.103

Polymorphisms and the antiviral property of porcine Mx1 protein.

1. The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus.

2. Association of multi-pathogenic infections with BAT2, CXCL12, Mx1 and EHMT2 variations in pigs.

Review 3. Mx proteins: antiviral gatekeepers that restrain the uninvited.

4. "Self" and "nonself" manipulation of interferon defense during persistent infection: bovine viral diarrhea virus resists alpha/beta interferon without blocking antiviral activity against unrelated viruses replicating in its host cells.

5. Effects of the polymorphisms of Mx1, BAT2 and CXCL12 genes on immunological traits in pigs.

6. Inhibition of infectious pancreatic necrosis virus replication by atlantic salmon Mx1 protein.

7. A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus.

8. African swine fever virus multigene family 360 and 530 genes affect host interferon response.

9. Porcine Mx1 Protein Inhibits Classical Swine Fever Virus Replication by Targeting Nonstructural Protein NS5B.

10. Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.