Literature DB >> 125199

Effect of coumarins on mitochondrial function.

M R Pai, N J Bai, T A Venkitasubramanian, V V Murthy.   

Abstract

Several derivatives of coumarin inhibited mitochondrial respiration and ATPase activity. The extent of inhibition depended on the concentration of the coumarins as well as on the substituents of the coumarin ring. Some of the coumarins stimulated ATPase activity, but all of them inhibited uncoupler-stimulated ATPase activity. Coumarins with free or substituted phenolic groups were found to exert profound effects on respiration and ATPase activity.

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Year:  1975        PMID: 125199

Source DB:  PubMed          Journal:  Environ Physiol Biochem        ISSN: 0300-5429


  2 in total

1.  Mammea E/BB, an isoprenylated dihydroxycoumarin protonophore that potently uncouples mitochondrial electron transport, disrupts hypoxic signaling in tumor cells.

Authors:  Lin Du; Fakhri Mahdi; Mika B Jekabsons; Dale G Nagle; Yu-Dong Zhou
Journal:  J Nat Prod       Date:  2010-10-07       Impact factor: 4.050

2.  Natural and semisynthetic mammea-type isoprenylated dihydroxycoumarins uncouple cellular respiration.

Authors:  Lin Du; Fakhri Mahdi; Mika B Jekabsons; Dale G Nagle; Yu-Dong Zhou
Journal:  J Nat Prod       Date:  2011-01-07       Impact factor: 4.050

  2 in total

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