R F Reynolds1, C M Obermeyer. 1. Safety Evaluation and Epidemiology, Pfizer, Inc., New York, NY 10017, USA. robert.reynolds@pfizer.com
Abstract
PRIMARY OBJECTIVE: To determine the median age of natural menopause and factors associated with the timing of menopause in Morocco. RESEARCH DESIGN: A population-based sample of 299 women from Rabat, Morocco were interviewed using a semi-structured questionnaire. METHODS AND PROCEDURES: Logit analysis and logistic regression were used to estimate the median age and identify factors associated with the age at menopause. MAIN OUTCOMES AND RESULTS: The median age of natural menopause in Morocco is estimated to be 48.4 years (95% CI: 36.9, 70.3). Women who reported the onset of menstruation at age 11 or younger (OR = 2.84, 95% CI: 1.00, 8.10) had an earlier age at menopause than women who started menstruating at age 12 or older. Women who had ever used oral contraceptives were more likely to have a later age at menopause (OR = 0.55, 95% CI: 0.30, 1.00). The length of time a woman used oral contraceptives influenced the timing of the menopause in unadjusted models but after adjusting for the age at menarche the effect was no longer statistically significant. Marital status, parity, education level, and social class were not statistically associated with the age at menopause. CONCLUSIONS: The estimated age at natural menopause in Morocco is 1-3 years earlier than the median ages reported in industrialized countries and some developing countries. Factors that alter the frequency of ovulation or rate of follicular atresia appear to be important in determining the age at menopause.
PRIMARY OBJECTIVE: To determine the median age of natural menopause and factors associated with the timing of menopause in Morocco. RESEARCH DESIGN: A population-based sample of 299 women from Rabat, Morocco were interviewed using a semi-structured questionnaire. METHODS AND PROCEDURES: Logit analysis and logistic regression were used to estimate the median age and identify factors associated with the age at menopause. MAIN OUTCOMES AND RESULTS: The median age of natural menopause in Morocco is estimated to be 48.4 years (95% CI: 36.9, 70.3). Women who reported the onset of menstruation at age 11 or younger (OR = 2.84, 95% CI: 1.00, 8.10) had an earlier age at menopause than women who started menstruating at age 12 or older. Women who had ever used oral contraceptives were more likely to have a later age at menopause (OR = 0.55, 95% CI: 0.30, 1.00). The length of time a woman used oral contraceptives influenced the timing of the menopause in unadjusted models but after adjusting for the age at menarche the effect was no longer statistically significant. Marital status, parity, education level, and social class were not statistically associated with the age at menopause. CONCLUSIONS: The estimated age at natural menopause in Morocco is 1-3 years earlier than the median ages reported in industrialized countries and some developing countries. Factors that alter the frequency of ovulation or rate of follicular atresia appear to be important in determining the age at menopause.
Authors: Jenifer E Allsworth; Sally Zierler; Kate L Lapane; Nancy Krieger; Joseph W Hogan; Bernard L Harlow Journal: J Epidemiol Community Health Date: 2004-11 Impact factor: 3.710
Authors: J A Schoenhard; F W Asselbergs; K A Poku; S A Stocki; S Gordon; D E Vaughan; N J Brown; J H Moore; Scott M Williams Journal: Hum Genet Date: 2008-10-25 Impact factor: 4.132
Authors: Kylee L Spencer; Jennifer Malinowski; Cara L Carty; Nora Franceschini; Lindsay Fernández-Rhodes; Alicia Young; Iona Cheng; Marylyn D Ritchie; Christopher A Haiman; Lynne Wilkens; Tara C Matise; Christopher S Carlson; Kathleen Brennan; Amy Park; Aleksandar Rajkovic; Lucia A Hindorff; Steven Buyske; Dana C Crawford Journal: PLoS One Date: 2013-02-12 Impact factor: 3.240