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Literature DB >> 12517700

Integration of signals to the Arp2/3 complex.

Alissa M Weaver¹, Michael E Young, Wei-Lih Lee, John A Cooper.

Abstract

The Arp2/3 complex is necessary for nucleating the formation of branched networks of actin filaments at the cell cortex, and an increasing number of proteins able to activate the Arp2/3 complex have been described. The Wiskott-Aldrich syndrome protein (WASP) family and cortactin comprise the large majority of the known activators. WASPs bind to Arp2/3 via an acidic (A) domain, and a WH2 domain appears to bring an actin monomer to Arp2/3, promoting the nucleation of the new filament. Cortactin also binds the Arp2/3 complex via an A domain; however, it also binds to actin filaments, which helps activate the Arp2/3 complex and stabilise the newly created branches between the filaments.

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Year: 2003 PMID： 12517700 DOI： 10.1016/s0955-0674(02)00015-7

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

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Cited

72 in total

1. Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes.

Authors: Claudia Bertuccio; Delma Veron; Pardeep K Aggarwal; Lawrence Holzman; Alda Tufro
Journal: J Biol Chem Date: 2011-09-21 Impact factor: 5.157

2. Beta1 and beta3 integrins cooperate to induce syndecan-4-containing cross-linked actin networks in human trabecular meshwork cells.

Authors: Mark S Filla; Anne Woods; Paul L Kaufman; Donna M Peters
Journal: Invest Ophthalmol Vis Sci Date: 2006-05 Impact factor: 4.799

Review 3. Cell migration and metastasis as targets of small RNA-based molecular genetic analyses.

Authors: Eigo Suyama; Hiroaki Kawasaki; Renu Wadhwa; Kazunari Taira
Journal: J Muscle Res Cell Motil Date: 2004 Impact factor: 2.698

4. Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis.

Authors: Pearl P Y Lie; Apple Y N Chan; Dolores D Mruk; Will M Lee; C Yan Cheng
Journal: Proc Natl Acad Sci U S A Date: 2010-06-07 Impact factor: 11.205

5. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.

Authors: Lulu Y Chen; Christopher S Rex; Alex H Babayan; Eniko A Kramár; Gary Lynch; Christine M Gall; Julie C Lauterborn
Journal: J Neurosci Date: 2010-08-18 Impact factor: 6.167

6. Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.

Authors: Peter W Reddien; Adam L Bermange; Kenneth J Murfitt; Joya R Jennings; Alejandro Sánchez Alvarado
Journal: Dev Cell Date: 2005-05 Impact factor: 12.270

Integration of signals to the Arp2/3 complex.

1. Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes.

2. Beta1 and beta3 integrins cooperate to induce syndecan-4-containing cross-linked actin networks in human trabecular meshwork cells.

Review 3. Cell migration and metastasis as targets of small RNA-based molecular genetic analyses.

4. Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis.

5. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.

6. Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria.

7. New slbo-Gal4 driver lines for the analysis of border cell migration during Drosophila oogenesis.

8. Drebrin and Spermatogenesis.

Review 9. Signaling in regulation of podocyte phenotypes.

10. Inhibiting the Arp2/3 complex limits infection of both intracellular mature vaccinia virus and primate lentiviruses.