| Literature DB >> 12517440 |
Wu Du1, Bashir Kaskar, Peter Blumbergs, P-K Subramanian, Dennis P Curran.
Abstract
Thiol- or acid-promoted additions of silyl radicals to camptothecin are reported. At 105 degrees C, mixtures of 7-silyl (favored) and 12-silyl camptothecins are formed alongside substantial amounts of recovered camptothecin. At 160 degrees C, 12-silyl isomers are formed preferentially, but the total mass balance is substantially reduced. The silyl radical addition is featured in short semi-syntheses of DB-67 (7-tert-butyldimethylsilyl-10-hydroxy camptothecin) from both camptothecin and 10-hydroxycamptothecin.Entities:
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Year: 2003 PMID： 12517440 DOI： 10.1016/s0968-0896(02)00437-6
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641