Literature DB >> 12516775

Monoclonal antibody to shiga toxin 1, which blocks receptor binding and neutralizes cytotoxicity.

Hiroshi Nakao1, Chiwa Kataoka, Nobutaka Kiyokawa, Junichiro Fujimoto, Shinji Yamasaki, Tae Takeda.   

Abstract

A monoclonal antibody, 5-5B, which neutralizes Shiga toxin 1 (Stx1) cytotoxicity of Escherichia coli, was constructed. An epitope analysis indicated that Asn55 in Stx1 B subunit was an important residue. This result and our previous results using an anti-Stx2 monoclonal antibody indicate that the region around the cysteine residue of the disulfide bond might be important for the neutralization of Stx cytotoxicity, making it a potential vaccination candidate.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12516775     DOI： 10.1111/j.1348-0421.2002.tb02764.x

Source DB:  PubMed          Journal:  Microbiol Immunol        ISSN： 0385-5600            Impact factor:   1.955


  5 in total

1.  The 13C4 monoclonal antibody that neutralizes Shiga toxin Type 1 (Stx1) recognizes three regions on the Stx1 B subunit and prevents Stx1 from binding to its eukaryotic receptor globotriaosylceramide.

Authors:  Michael J Smith; Humberto M Carvalho; Angela R Melton-Celsa; Alison D O'Brien
Journal:  Infect Immun       Date:  2006-10-09       Impact factor: 3.441

2.  Impact of the nature and size of the polymeric backbone on the ability of heterobifunctional ligands to mediate shiga toxin and serum amyloid p component ternary complex formation.

Authors:  Pavel I Kitov; Eugenia Paszkiewicz; Joanna M Sadowska; Zhicheng Deng; Marya Ahmed; Ravin Narain; Thomas P Griener; George L Mulvey; Glen D Armstrong; David R Bundle
Journal:  Toxins (Basel)       Date:  2011-08-25       Impact factor: 4.546

Review 3.  Monoclonal antibodies and toxins--a perspective on function and isotype.

Authors:  Siu-Kei Chow; Arturo Casadevall
Journal:  Toxins (Basel)       Date:  2012-06-11       Impact factor: 4.546

Review 4.  Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives.

Authors:  Izabella de Macedo Henrique; Flavia Sacerdoti; Raissa Lozzardo Ferreira; Camila Henrique; Maria Marta Amaral; Roxane Maria Fontes Piazza; Daniela Luz
Journal:  Front Cell Infect Microbiol       Date:  2022-02-10       Impact factor: 5.293

5.  Interaction between Shiga toxin and monoclonal antibodies: binding characteristics and in vitro neutralizing abilities.

Authors:  Letícia B Rocha; Daniela E Luz; Claudia T P Moraes; Andressa Caravelli; Irene Fernandes; Beatriz E C Guth; Denise S P Q Horton; Roxane M F Piazza
Journal:  Toxins (Basel)       Date:  2012-09-18       Impact factor: 4.546
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.