Xinjian Kuang1, Kexian Ma, Tiwu Duan. 1. Department of Burns, The Second Affiliated Hospital of Kunming Medical College, Kunming 650000 Yunnan Province, P.R. China.
Abstract
OBJECTIVE: To observe the postburn changes in the plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage. METHODS: Nineteen burn patients were enrolled in the study. The plasma levels of the above 3 kinds of factors were determined with ELISA in the peripheral plasma of the patients, plasma samples from 11 healthy volunteers were taken as the control. RESULTS: The plasma levels of ICAM-1, IL-10 and TNFalpha increased obviously postburn, especially in those patients who were complicated with hypovolumic shock, sepsis and MODS (P < 0.05 - 0.01). CONCLUSION: The monitoring of the postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha might be helpful in the forecast of postburn sepsis and the development of MODS.
OBJECTIVE: To observe the postburn changes in the plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage. METHODS: Nineteen burn patients were enrolled in the study. The plasma levels of the above 3 kinds of factors were determined with ELISA in the peripheral plasma of the patients, plasma samples from 11 healthy volunteers were taken as the control. RESULTS: The plasma levels of ICAM-1, IL-10 and TNFalpha increased obviously postburn, especially in those patients who were complicated with hypovolumic shock, sepsis and MODS (P < 0.05 - 0.01). CONCLUSION: The monitoring of the postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha might be helpful in the forecast of postburn sepsis and the development of MODS.
Authors: Cressida Mahung; Wesley H Stepp; Clayton Long; Madison Malfitano; Irmak Saklayici; Shannon M Wallet; Laura Y Zhou; Haibo Zhou; Bruce A Cairns; Robert Maile Journal: J Trauma Acute Care Surg Date: 2022-03-30 Impact factor: 3.697