Literature DB >> 12515090

[Ani immunomodulator Hepon inhibits hepatitis C virus replication in human cell cultures in vitro].

R I Ataullakhanov, R D Holms, A V Katlinskiĭ, P G Deriabin, A N Narovlianskiĭ, M V Mezentseva, F I Ershov.   

Abstract

Antiviral activity of immunomodulator "Hepon" was evaluated in human cells culture infected with hepatitis C virus. "Hepon" presence protected human cells SW-13 from cytopathogenic effect of hepatitis C virus. Maximum antiviral effect was demonstrated by "Hepon" at concentration 1 mcg/mL. Control antiviral agent reaferon (interferon alfa-2a) was more potent as vitality protecting agent in the case of SW-13 human cells culture. "Hepon" activity is based on changes of cytokins and interferons spectrum so this immunomodulator is expected to be effective against different viruses including herpes virus and encephalocarditis virus.

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Year:  2002        PMID: 12515090

Source DB:  PubMed          Journal:  Antibiot Khimioter        ISSN: 0235-2990


  1 in total

1.  Novel mutation in YMDD motif and direct neighbourhood in a child with chronic HBV-infection and clinical lamivudine and adefovir resistance - a scholarly case.

Authors:  Verena Schildgen; Susanne Ziegler; Ramona L Tillmann; Oliver Schildgen
Journal:  Virol J       Date:  2010-07-21       Impact factor: 4.099

  1 in total

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