| Literature DB >> 12514734 |
Erin Janssen1, Minghua Zhu, Weijia Zhang, Surapong Koonpaew, Weiguo Zhang.
Abstract
The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT(-/-) mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways.Entities:
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Year: 2003 PMID： 12514734 DOI： 10.1038/ni882
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606