Literature DB >> 12514581

Does severe venous insufficiency have a different etiology in the morbidly obese? Is it venous?

Frank Padberg1, Joaquim J Cerveira, Brajesh K Lal, Peter J Pappas, Shubha Varma, Robert W Hobson.   

Abstract

OBJECTIVE: Chronic venous insufficiency (CVI) is the most common cause of leg ulcers. Patients with morbid obesity are remarkable for particularly recalcitrant ulcers. Because obesity is not specifically incorporated in CEAP or other venous scoring systems, we sought to characterize this group of patients more completely.
METHODS: Patients with severe CVI (CEAP clinical class, 4, 5, and 6), and class III obesity (body mass index [BMI], >40) were reviewed. Findings from clinical and duplex ultrasound scan (DU) examinations were compared with the CEAP classification, its adjunctive venous clinical severity score, and sensory thresholds.
RESULTS: A review of clinic records identified 20 ambulatory patients with a mean age of 62 years, a mean BMI of 52, and a mean weight of 164 kg (361 lbs); all but one had bilateral symptoms. No evidence of venous insufficiency was detected with DU in 24 of the 39 limbs. Although some valvular incompetence was detected with DU in 15 of 39 limbs, these abnormalities were widely dispersed between 28 sites; eight limbs had findings at only one site. Ulceration (mean area, 29 cm(2)) was present in 25 limbs and necessitated 7 months for healing; 13 (52%) recurred at least once during a mean observation period of 36 months. The mean sensory threshold of 5.21 exceeded current risk thresholds used in diabetic screening programs. The distribution of CEAP clinical class was C4 (n = 14), C5 (n = 14), and C6 (n = 11). Increasing CEAP class correlated with an increased mean BMI of 47, 52, and 56, respectively (P <.01). CEAP also correlated with a rising mean venous clinical severity score of 10, 11, and 15, respectively (P <.05).
CONCLUSION: Patients with class III obesity had severe limb symptoms, typical of CVI, but approximately two thirds of the limbs had no anatomic evidence of venous disease. The association of increasing limb symptoms with increasing obesity suggested that the obesity itself contributes to the morbidity.

Entities:  

Mesh:

Year:  2003        PMID: 12514581     DOI: 10.1067/mva.2003.61

Source DB:  PubMed          Journal:  J Vasc Surg        ISSN: 0741-5214            Impact factor:   4.268


  9 in total

1.  Adipokines are associated with lower extremity venous disease: the San Diego population study.

Authors:  M A Allison; M Cushman; P W Callas; J O Denenberg; N E Jensky; M H Criqui
Journal:  J Thromb Haemost       Date:  2010-09       Impact factor: 5.824

2.  Managing weighty issues on lean evidence: the challenges of bariatric medicine.

Authors:  Arya M Sharma
Journal:  CMAJ       Date:  2005-01-04       Impact factor: 8.262

3.  Risk Factors in Patients with Venous Stasis-Related Skin Lesions without Major Abnormalities on Duplex Ultrasonography.

Authors:  Kotaro Suehiro; Noriyasu Morikage; Osamu Yamashita; Takasuke Harada; Makoto Samura; Yuriko Takeuchi; Takahiro Mizoguchi; Kimikazu Hamano
Journal:  Ann Vasc Dis       Date:  2016-08-29

4.  [Ulcers in obesity-associated chronic venous insufficiency].

Authors:  L Scholl; M Dörler; M Stücker
Journal:  Hautarzt       Date:  2017-07       Impact factor: 0.751

5.  The evaluation of lower-extremity ulcers.

Authors:  Georgios Spentzouris; Nicos Labropoulos
Journal:  Semin Intervent Radiol       Date:  2009-12       Impact factor: 1.513

6.  Effect of nordic walking and water aerobics training on body composition and the blood flow in lower extremities in elderly women.

Authors:  Ryszard Jasiński; Małgorzata Socha; Ludmiła Sitko; Katarzyna Kubicka; Marek Woźniewski; Krzysztof A Sobiech
Journal:  J Hum Kinet       Date:  2015-04-07       Impact factor: 2.193

7.  The Effect of Body Mass Index on Outcome Following Ambulatory High Ligation and Stripping for Lower Varicose Veins: A Prospective Cohort Study.

Authors:  Chu Wen Chen; Yu T Cai; Jia R Wang; Zhou P Wu; Yang Liu; Bing Huang; Yi Yang; Ding Yuan; Yu K Ma; Ji C Zhao
Journal:  Front Surg       Date:  2022-04-04

8.  Correlation of obesity & comorbid conditions with chronic venous insufficiency: Results of a single-centre study.

Authors:  Sandeep Mahapatra; Pinjala Ramakrishna; Bhumika Gupta; Arumalla Anusha; Muneer Ahmad Para
Journal:  Indian J Med Res       Date:  2018-05       Impact factor: 2.375

9.  Combined therapy in the treatment of mixed etiology leg ulcer - case report.

Authors:  Jarosław Pasek; Grzegorz Cieślar; Aleksander Sieroń
Journal:  Ther Clin Risk Manag       Date:  2018-10-08       Impact factor: 2.423

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.