Literature DB >> 12513183

Solvable senescence model showing a mortality plateau.

J B Coe1, Y Mao, M E Cates.   

Abstract

We present some analytic results for the steady states of the Penna model of senescence, generalized to allow genetically identical individuals to die at different ages via an arbitrary survival function. Modeling this with a Fermi function (of modest width) we obtain a clear mortality plateau late in life: something that has so far eluded explanation within such mutation accumulation models. This suggests that factors causing variable mortality within genetically identical subpopulations, which include environmental effects, may be essential to understanding the mortality plateau seen in many real species.

Year:  2002        PMID: 12513183     DOI: 10.1103/PhysRevLett.89.288103

Source DB:  PubMed          Journal:  Phys Rev Lett        ISSN: 0031-9007            Impact factor:   9.161


  4 in total

1.  Stability of the analytical solution of Penna model of biological aging.

Authors:  M S Magdoń-Maksymowicz
Journal:  Theory Biosci       Date:  2008-10-22       Impact factor: 1.919

2.  Epigenetic contribution to age distribution of mortality within the Penna model.

Authors:  M S Magdoń-Maksymowicz; A Z Maksymowicz
Journal:  Theory Biosci       Date:  2015-02-10       Impact factor: 1.919

3.  Plasticity and rectangularity in survival curves.

Authors:  Byung Mook Weon; Jung Ho Je
Journal:  Sci Rep       Date:  2011-09-28       Impact factor: 4.379

4.  The penna model of biological aging.

Authors:  D Stauffer
Journal:  Bioinform Biol Insights       Date:  2009-11-24
  4 in total

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