Andre Mochan1, Mala Modi, Girish Modi. 1. Division of Neurology, Department of Neurosciences, Faculty of Health Sciences, University of the Witwatersrand, Parktown, Johannesburg, South Africa.
Abstract
BACKGROUND AND PURPOSE: Stroke associated with HIV infection is poorly characterized. In this study we analyze the association in a black African population. METHODS: The clinical, laboratory, and radiological characteristics of 35 hospital-based black South African, heterosexual, HIV-infected patients who did not abuse intravenous drugs and presented with strokes were prospectively studied. The patients were antiretroviral therapy naive. Patients with other intracranial space-occupying lesions were excluded from the study. RESULTS: The age range was 20 to 61 years (mean, 32.1 years). There were 21 female and 14 male patients, with a female to male ratio of 1.5:1. Cerebral infarction occurred in 33 patients (94%) and intracerebral hemorrhage in 2 patients (6%). Underlying causes were identified in 30 of the 35 patients (86%) and included coagulopathies, meningitis, cardioembolism, and hypertension. The most common coagulopathy was protein S deficiency. No cause was found in 5 patients (14%). CONCLUSIONS: The results are similar to data from studies on young black African stroke patients who are HIV negative.
BACKGROUND AND PURPOSE:Stroke associated with HIV infection is poorly characterized. In this study we analyze the association in a black African population. METHODS: The clinical, laboratory, and radiological characteristics of 35 hospital-based black South African, heterosexual, HIV-infectedpatients who did not abuse intravenous drugs and presented with strokes were prospectively studied. The patients were antiretroviral therapy naive. Patients with other intracranial space-occupying lesions were excluded from the study. RESULTS: The age range was 20 to 61 years (mean, 32.1 years). There were 21 female and 14 male patients, with a female to male ratio of 1.5:1. Cerebral infarction occurred in 33 patients (94%) and intracerebral hemorrhage in 2 patients (6%). Underlying causes were identified in 30 of the 35 patients (86%) and included coagulopathies, meningitis, cardioembolism, and hypertension. The most common coagulopathy was protein S deficiency. No cause was found in 5 patients (14%). CONCLUSIONS: The results are similar to data from studies on young black African strokepatients who are HIV negative.
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