Literature DB >> 12509767

Metastasis suppressors alter the signal transduction of cancer cells.

Patricia S Steeg1.   

Abstract

Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified. These affect important signal-transduction pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled and tyrosine-kinase receptors. So how might we use this knowledge to improve the treatment of patients with cancer?

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Mesh：

Year:  2003        PMID： 12509767     DOI： 10.1038/nrc967

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  182 in total

Review 1.  Cell invasion through basement membrane: the anchor cell breaches the barrier.

Authors:  Elliott J Hagedorn; David R Sherwood
Journal:  Curr Opin Cell Biol       Date:  2011-05-31       Impact factor: 8.382

Review 2.  Role of TLR2-dependent inflammation in metastatic progression.

Authors:  Sunhwa Kim; Michael Karin
Journal:  Ann N Y Acad Sci       Date:  2011-01       Impact factor: 5.691

Review 3.  Treating metastatic cancer with nanotechnology.

Authors:  Avi Schroeder; Daniel A Heller; Monte M Winslow; James E Dahlman; George W Pratt; Robert Langer; Tyler Jacks; Daniel G Anderson
Journal:  Nat Rev Cancer       Date:  2011-12-23       Impact factor: 60.716

Review 4.  Genome organizing function of SATB1 in tumor progression.

Authors:  Terumi Kohwi-Shigematsu; Krzysztof Poterlowicz; Ellen Ordinario; Hye-Jung Han; Vladimir A Botchkarev; Yoshinori Kohwi
Journal:  Semin Cancer Biol       Date:  2012-07-04       Impact factor: 15.707

Review 5.  New insights into the tumor metastatic process revealed by gene expression profiling.

Authors:  Patricia S Steeg
Journal:  Am J Pathol       Date:  2005-05       Impact factor: 4.307

6.  Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1.

Authors:  Yeong-Gwan Park; Xiaohong Zhao; Fabienne Lesueur; Douglas R Lowy; Mindy Lancaster; Paul Pharoah; Xiaolan Qian; Kent W Hunter
Journal:  Nat Genet       Date:  2005-09-04       Impact factor: 38.330

Review 7.  Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application.

Authors:  Carrie W Rinker-Schaeffer; James P O'Keefe; Danny R Welch; Dan Theodorescu
Journal:  Clin Cancer Res       Date:  2006-07-01       Impact factor: 12.531

Review 8.  Tetraspanins: push and pull in suppressing and promoting metastasis.

Authors:  Margot Zöller
Journal:  Nat Rev Cancer       Date:  2008-12-11       Impact factor: 60.716

Review 9.  Clinical-translational approaches to the Nm23-H1 metastasis suppressor.

Authors:  Patricia S Steeg; Christine E Horak; Kathy D Miller
Journal:  Clin Cancer Res       Date:  2008-08-15       Impact factor: 12.531

10.  A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene.

Authors:  Stephane Gobeil; Xiaochun Zhu; Charles J Doillon; Michael R Green
Journal:  Genes Dev       Date:  2008-11-01       Impact factor: 11.361
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