| Literature DB >> 12508160 |
Richard F Little1, Florentino Merced-Galindez, Katherine Staskus, Denise Whitby, Yoshiyasu Aoki, Rachel Humphrey, James M Pluda, Vickie Marshall, Michael Walters, Lauri Welles, Isaac R Rodriguez-Chavez, Stefania Pittaluga, Giovanna Tosato, Robert Yarchoan.
Abstract
A clinical trial was conducted to test the activity of cidofovir (CDV), a drug with in vitro activity against Kaposi sarcoma (KS)-associated herpesvirus (KSHV), in KS. Five patients with human immunodeficiency virus-associated KS (4 receiving antiretroviral therapy) and 2 patients with classical KS were administered CDV (5 mg/kg/dose) weekly for 2 weeks and then every other week. All 7 patients had progression of their KS at a median of 8.1 weeks (range, 5-27 weeks). Skin biopsy specimens of KS lesions showed no change in expression of latent or early lytic genes, but, in the 1 assessable patient, there was decreased expression of a late lytic gene. There was no decrease in the virus load of KSHV in peripheral blood mononuclear cells. This study does not provide proof of principle for the treatment of KS with CDV. However, it remains possible that antiherpesvirus therapy can be developed for herpes-induced tumors.Entities:
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Year: 2002 PMID： 12508160 DOI： 10.1086/346159
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226