Literature DB >> 12508038

Gene therapy for the treatment of oral squamous cell carcinoma.

S Xi1, J R Grandis.   

Abstract

Despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with oral squamous cell carcinoma has not significantly improved over the past several decades. Treatment options for recurrent or refractory oral cancers are limited. Gene therapy for oral cancer is currently under investigation in clinical trials. The goal of cancer gene therapy is to introduce new genetic material into target cells without toxicity to non-target tissues. This review discusses the techniques used in cancer gene therapy for oral squamous cell carcinoma and summarizes the ongoing strategies that are being evaluated in clinical trials.

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Year:  2003        PMID： 12508038     DOI： 10.1177/154405910308200104

Source DB:  PubMed          Journal:  J Dent Res        ISSN： 0022-0345            Impact factor:   6.116


  26 in total

1.  Alkylation-induced genotoxicity as a predictor of DNA repair deficiency following experimental oral carcinogenesis.

Authors:  Juliana G Carvalho; Juliana Noguti; Victor Hugo P da Silva; Rogério A Dedivitis; Marcello Franco; Daniel A Ribeiro
Journal:  J Mol Histol       Date:  2012-04       Impact factor: 2.611

2.  The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines.

Authors:  Jason S White; Joel L Weissfeld; Camille C R Ragin; Karen M Rossie; Christa Lese Martin; Michele Shuster; Chandramohan S Ishwad; John C Law; Eugene N Myers; Jonas T Johnson; Susanne M Gollin
Journal:  Oral Oncol       Date:  2006-11-16       Impact factor: 5.337

3.  Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide.

Authors:  Daniel A Ribeiro; Daisy M F Salvadori; Mariângela E A Marques
Journal:  Int J Exp Pathol       Date:  2005-12       Impact factor: 1.925

4.  Cigarette smoke affects apoptosis in rat tongue mucosa: role of bcl-2 gene family.

Authors:  Gerson F Assis; Daniele S Ceolin; Mariângela E A Marques; Daisy M F Salvadori; Daniel A Ribeiro
Journal:  J Mol Histol       Date:  2006-05-09       Impact factor: 2.611

5.  RNAi targeting CXCR4 inhibits tumor growth through inducing cell cycle arrest and apoptosis.

Authors:  Tao Yu; Yingying Wu; Yi Huang; Chaoran Yan; Ying Liu; Zongsheng Wang; Xiaoyi Wang; Yuming Wen; Changmei Wang; Longjiang Li
Journal:  Mol Ther       Date:  2011-11-22       Impact factor: 11.454

6.  Gene therapy in oral cancer: a review.

Authors:  M Sathish Kumar; K M K Masthan; N Aravindha Babu; Kailash Chandra Dash
Journal:  J Clin Diagn Res       Date:  2013-06-01

7.  Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats.

Authors:  Daniel A Ribeiro; Daniela G Grilli; Daisy M F Salvadori
Journal:  J Mol Histol       Date:  2008-08-01       Impact factor: 2.611

8.  Overexpression of MARCKS indicates a poor prognosis of oral squamous cell carcinoma.

Authors:  Chengjing Li; Rong Xia; Haowei Xue; Yukun Hu; Ming Sun; Dongdong Fang; Wenyu Yang; Feng Xiao; Jun Hou
Journal:  Oncol Lett       Date:  2018-08-16       Impact factor: 2.967

9.  Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.

Authors:  Biljana Culjkovic; Katherine L Borden
Journal:  J Oncol       Date:  2009-12-13       Impact factor: 4.375

10.  Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells.

Authors:  K Saito; K Uzawa; A Kasamatsu; K Shinozuka; K Sakuma; M Yamatoji; M Shiiba; Y Shino; H Shirasawa; H Tanzawa
Journal:  Br J Cancer       Date:  2009-07-28       Impact factor: 7.640
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