Literature DB >> 12507841

Lysis of methicillin-resistant Staphylococcus aureus by 2,4-diacetylphloroglucinol produced by Pseudomonas sp. AMSN isolated from a marine alga.

Yuto Kamei1, Alim Isnansetyo.   

Abstract

Previously 2,4-diacetylphloroglucinol (DAPG) produced by Pseudomonas sp. AMSN isolated from a marine alga, had demonstrated a high level of anti-methicillin-resistant Staphylococcus aureus (MRSA) comparable with that of vancomycin. In this study, this substance had bacteriolytic activity against MRSA at 1 microg/ml as well as similar activity against Vibrio parahaemolyticus at 24 microg/ml that suggests a novel antibacterial mode of action by this substance. Heat and pH stability tests showed it to be stable at temperatures ranging from 35 to 70 degrees C and at pHs ranging from 2-7. It was not acutely toxic to mice at levels up to 100 mg/kg.

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Year:  2003        PMID： 12507841     DOI： 10.1016/s0924-8579(02)00251-0

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  15 in total

1.  Growth inhibition and excessive branching in Aphanomyces cochlioides induced by 2,4-diacetylphloroglucinol is linked to disruption of filamentous actin cytoskeleton in the hyphae.

Authors:  Md Tofazzal Islam; Yukiharu Fukushi
Journal:  World J Microbiol Biotechnol       Date:  2009-12-25       Impact factor: 3.312

2.  Saccharomyces cerevisiae genome-wide mutant screen for sensitivity to 2,4-diacetylphloroglucinol, an antibiotic produced by Pseudomonas fluorescens.

Authors:  Youn-Sig Kwak; Sangjo Han; Linda S Thomashow; Jennifer T Rice; Timothy C Paulitz; Dongsup Kim; David M Weller
Journal:  Appl Environ Microbiol       Date:  2010-12-30       Impact factor: 4.792

Review 3.  Algal Phlorotannins as Novel Antibacterial Agents with Reference to the Antioxidant Modulation: Current Advances and Future Directions.

Authors:  Biswajita Pradhan; Rabindra Nayak; Prajna Paramita Bhuyan; Srimanta Patra; Chhandashree Behera; Sthitaprajna Sahoo; Jang-Seu Ki; Alessandra Quarta; Andrea Ragusa; Mrutyunjay Jena
Journal:  Mar Drugs       Date:  2022-06-18       Impact factor: 6.085

Review 4.  Novel anti-infective compounds from marine bacteria.

Authors:  Hafizur Rahman; Brian Austin; Wilfrid J Mitchell; Peter C Morris; Derek J Jamieson; David R Adams; Andrew Mearns Spragg; Michael Schweizer
Journal:  Mar Drugs       Date:  2010-03-05       Impact factor: 5.118

Review 5.  Immense essence of excellence: marine microbial bioactive compounds.

Authors:  Ira Bhatnagar; Se-Kwon Kim
Journal:  Mar Drugs       Date:  2010-10-15       Impact factor: 5.118

6.  Identification of a Pseudomonas sp. that Inhibits RHL System of Quorum Sensing.

Authors:  Yuanyuan Zhang; Yuqian Zhang; Yuxiang Yang; Lianhui Wang; Lixing Weng
Journal:  Indian J Microbiol       Date:  2013-01-25       Impact factor: 2.461

Review 7.  Bioactive substances produced by marine isolates of Pseudomonas.

Authors:  Alim Isnansetyo; Yuto Kamei
Journal:  J Ind Microbiol Biotechnol       Date:  2009-07-07       Impact factor: 3.346

8.  Anti-leukemic, anti-lung, and anti-breast cancer potential of the microbial polyketide 2, 4-diacetylphloroglucinol (DAPG) and its interaction with the metastatic proteins than the antiapoptotic Bcl-2 proteins.

Authors:  Vijay Kumar Veena; Kamaraj Kennedy; Pragna Lakshmi; R Krishna; N Sakthivel
Journal:  Mol Cell Biochem       Date:  2016-02-01       Impact factor: 3.396

9.  2,4-Diacetylphloroglucinol suppresses zoosporogenesis and impairs motility of Peronosporomycete zoospores.

Authors:  M Tofazzal Islam; Andreas von Tiedemann
Journal:  World J Microbiol Biotechnol       Date:  2011-02-02       Impact factor: 3.312

Review 10.  Pseudomonas putida-a versatile host for the production of natural products.

Authors:  Anita Loeschcke; Stephan Thies
Journal:  Appl Microbiol Biotechnol       Date:  2015-06-23       Impact factor: 4.813
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