Literature DB >> 12507427

RNA polymerase I propagates unidirectional spreading of rDNA silent chromatin.

Stephen W Buck1, Joseph J Sandmeier, Jeffrey S Smith.   

Abstract

The ribosomal DNA (rDNA) tandem array in Saccharomyces cerevisiae induces transcriptional silencing of RNA polymerase II-transcribed genes. This SIR2-dependent form of repression (rDNA silencing) also functions to limit rDNA recombination and is involved in life span control. In this report, we demonstrate that rDNA silencing spreads into the centromere-proximal unique sequence located downstream of RNA polymerase I (Pol I) transcription, but fails to enter the upstream telomere-proximal sequences. The spreading of silencing correlates with SIR2-dependent histone H3 and H4 deacetylation and can be extended by SIR2 overexpression. Surprisingly, rDNA silencing required transcription by RNA polymerase I and the direction of spreading was controlled by the direction of Pol I transcription.

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Year:  2002        PMID： 12507427     DOI： 10.1016/s0092-8674(02)01193-5

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  45 in total

1.  The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.

Authors:  Donald L Pappas; Ryan Frisch; Michael Weinreich
Journal:  Genes Dev       Date:  2004-04-01       Impact factor: 11.361

2.  Replication fork arrest and rDNA silencing are two independent and separable functions of the replication terminator protein Fob1 of Saccharomyces cerevisiae.

Authors:  Narendra K Bairwa; Shamsu Zzaman; Bidyut K Mohanty; Deepak Bastia
Journal:  J Biol Chem       Date:  2010-02-23       Impact factor: 5.157

3.  Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing.

Authors:  Agnès H Michel; Benoît Kornmann; Karine Dubrana; David Shore
Journal:  Genes Dev       Date:  2005-05-15       Impact factor: 11.361

4.  Sir2 represses endogenous polymerase II transcription units in the ribosomal DNA nontranscribed spacer.

Authors:  Chonghua Li; John E Mueller; Mary Bryk
Journal:  Mol Biol Cell       Date:  2006-06-28       Impact factor: 4.138

5.  New alleles of SIR2 define cell-cycle-specific silencing functions.

Authors:  Mirela Matecic; Kristen Martins-Taylor; Merrit Hickman; Jason Tanny; Danesh Moazed; Scott G Holmes
Journal:  Genetics       Date:  2006-06-18       Impact factor: 4.562

6.  Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer.

Authors:  Julie Huang; Ilana L Brito; Judit Villén; Steven P Gygi; Angelika Amon; Danesh Moazed
Journal:  Genes Dev       Date:  2006-10-15       Impact factor: 11.361

7.  The LRS and SIN domains: two structurally equivalent but functionally distinct nucleosomal surfaces required for transcriptional silencing.

Authors:  Christopher J Fry; Anne Norris; Michael Cosgrove; Jef D Boeke; Craig L Peterson
Journal:  Mol Cell Biol       Date:  2006-10-02       Impact factor: 4.272

8.  The histone deubiquitinating enzyme Ubp10 is involved in rDNA locus control in Saccharomyces cerevisiae by affecting Sir2p association.

Authors:  Luciano Calzari; Ivan Orlandi; Lilia Alberghina; Marina Vai
Journal:  Genetics       Date:  2006-10-08       Impact factor: 4.562

9.  Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes.

Authors:  Jonathan A Claypool; Sarah L French; Katsuki Johzuka; Kristilyn Eliason; Loan Vu; Jonathan A Dodd; Ann L Beyer; Masayasu Nomura
Journal:  Mol Biol Cell       Date:  2003-10-31       Impact factor: 4.138

10.  A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae.

Authors:  Marguerite P Andersen; Zara W Nelson; Elizabeth D Hetrick; Daniel E Gottschling
Journal:  Genetics       Date:  2008-06-18       Impact factor: 4.562
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