Literature DB >> 12505753

Ob/ob mice as a model of delayed gastric emptying.

Akihiro Asakawa1, Akio Inui, Naohiko Ueno, Susumu Makino, Masaharu Uemoto, Masayuki A Fujino, Masato Kasuga.   

Abstract

Diabetic gastroparesis is a well-recognized delay of gastric emptying in diabetic patients. We assessed the gastric emptying rate in ob/ob mice, a genetic model of obesity and diabetes. The basal gastric emptying rate in 22- to 27-week-old ob/ob mice was significantly lower than that in 10- to 11-week-old ob/ob mice (P<.01). Our results indicate that the ob/ob mice are a useful model not only of glucose intolerance but also of delayed gastric emptying as a diabetic complication.

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Year:  2003        PMID： 12505753     DOI： 10.1016/s1056-8727(02)00198-8

Source DB:  PubMed          Journal:  J Diabetes Complications        ISSN： 1056-8727            Impact factor:   2.852


  16 in total

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3.  GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility.

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Review 4.  Rapid gastric emptying in diabetes mellitus: Pathophysiology and clinical importance.

Authors:  Raj K Goyal; Vivian Cristofaro; Maryrose P Sullivan
Journal:  J Diabetes Complications       Date:  2019-08-08       Impact factor: 2.852

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8.  The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet.

Authors:  V Di Marzo; R Capasso; I Matias; G Aviello; S Petrosino; F Borrelli; B Romano; P Orlando; F Capasso; A A Izzo
Journal:  Br J Pharmacol       Date:  2008-01-28       Impact factor: 8.739

9.  Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice.

Authors:  Mohamed A Fouad Shalaby; Hekma A Abd El Latif; Mostafa E El Sayed
Journal:  World J Gastrointest Pharmacol Ther       Date:  2013-05-06

10.  Impaired contractile responses and altered expression and phosphorylation of Ca(2+) sensitization proteins in gastric antrum smooth muscles from ob/ob mice.

Authors:  Bhupal P Bhetwal; Changlong An; Salah A Baker; Kristin L Lyon; Brian A Perrino
Journal:  J Muscle Res Cell Motil       Date:  2013-04-11       Impact factor: 2.698
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