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Literature DB >> 12504001

BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?

Simon N Powell¹, Henning Willers, Fen Xia.

Abstract

The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA.

Entities: Disease Gene

Mesh：

Substances：

Year: 2002 PMID： 12504001 DOI： 10.1016/s1097-2765(02)00789-x

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

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Cited

17 in total

1. Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.

Authors: Min Kyung Shinn; Alexander G Kozlov; Timothy M Lohman
Journal: Nucleic Acids Res Date: 2021-02-26 Impact factor: 16.971

2. Discriminatory suppression of homologous recombination by p53.

Authors: Sheng Yun; Chadwick Lie-A-Cheong; Andrew C G Porter
Journal: Nucleic Acids Res Date: 2004-12-15 Impact factor: 16.971

3. Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response.

Authors: Feng Zhang; Jiazhong Shi; Chunjing Bian; Xiaochun Yu
Journal: Cell Rep Date: 2015-10-17 Impact factor: 9.423

Review 4. Evaluation of rucaparib and companion diagnostics in the PARP inhibitor landscape for recurrent ovarian cancer therapy.

Authors: Zachary B Jenner; Anil K Sood; Robert L Coleman
Journal: Future Oncol Date: 2016-04-18 Impact factor: 3.404

Review 5. BRCA1 and BRCA2: different roles in a common pathway of genome protection.

Authors: Rohini Roy; Jarin Chun; Simon N Powell
Journal: Nat Rev Cancer Date: 2011-12-23 Impact factor: 60.716

6. Low Dose Gamma Irradiation of Trypanosoma evansi Parasites Identifies Molecular Changes That Occur to Repair Radiation Damage and Gene Transcripts That May Be Involved in Establishing Disease in Mice Post-Irradiation.

Authors: Richard T Kangethe; Eva M Winger; Tirumala Bharani K Settypalli; Sneha Datta; Viskam Wijewardana; Charles E Lamien; Hermann Unger; Theresa H T Coetzer; Giovanni Cattoli; Adama Diallo
Journal: Front Immunol Date: 2022-05-13 Impact factor: 8.786

BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?

1. Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.

2. Discriminatory suppression of homologous recombination by p53.

3. Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response.

Review 4. Evaluation of rucaparib and companion diagnostics in the PARP inhibitor landscape for recurrent ovarian cancer therapy.

Review 5. BRCA1 and BRCA2: different roles in a common pathway of genome protection.

6. Low Dose Gamma Irradiation of Trypanosoma evansi Parasites Identifies Molecular Changes That Occur to Repair Radiation Damage and Gene Transcripts That May Be Involved in Establishing Disease in Mice Post-Irradiation.

7. BRCA2 is required for neurogenesis and suppression of medulloblastoma.

8. Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.

9. Mechanism of RecO recruitment to DNA by single-stranded DNA binding protein.

10. BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.