Literature DB >> 12503997

Aha, another regulator for hsp90 chaperones.

Matthias P Mayer1, Rainer Nikolay, Bernd Bukau.   

Abstract

A large number of key regulators controlling homeostasis and cell fate are chaperoned by the Hsp90 folding machine. In this issue of Molecular Cell, report the discovery of a new stress-regulated cochaperone, Aha1, which accelerates the dynamics of this machine.

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Year:  2002        PMID： 12503997     DOI： 10.1016/s1097-2765(02)00793-1

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  12 in total

1.  Hsp90 cochaperone Aha1 is a negative regulator of the Saccharomyces MAL activator and acts early in the chaperone activation pathway.

Authors:  Fulai Ran; Nidhi Gadura; Corinne A Michels
Journal:  J Biol Chem       Date:  2010-02-22       Impact factor: 5.157

Review 2.  Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease.

Authors:  Laura J Blair; Jonathan J Sabbagh; Chad A Dickey
Journal:  Expert Opin Ther Targets       Date:  2014-07-29       Impact factor: 6.902

3.  Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein.

Authors:  Umesh K Jinwal; Jose F Abisambra; Juan Zhang; Sheetal Dharia; John C O'Leary; Tina Patel; Kaitlyn Braswell; Twisha Jani; Jason E Gestwicki; Chad A Dickey
Journal:  J Biol Chem       Date:  2012-06-06       Impact factor: 5.157

4.  Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle.

Authors:  Jing Li; Klaus Richter; Jochen Reinstein; Johannes Buchner
Journal:  Nat Struct Mol Biol       Date:  2013-02-10       Impact factor: 15.369

5.  The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

Authors:  Umesh K Jinwal; John Koren; Sergiy I Borysov; Andreas B Schmid; Jose F Abisambra; Laura J Blair; Amelia G Johnson; Jeffrey R Jones; Cody L Shults; John C O'Leary; Ying Jin; Johannes Buchner; Marc B Cox; Chad A Dickey
Journal:  J Neurosci       Date:  2010-01-13       Impact factor: 6.167

6.  Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1.

Authors:  David M Taylor; Miranda L Tradewell; Sandra Minotti; Heather D Durham
Journal:  Cell Stress Chaperones       Date:  2007       Impact factor: 3.667

7.  Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle.

Authors:  Michael Reidy; Shailesh Kumar; D Eric Anderson; Daniel C Masison
Journal:  Genetics       Date:  2018-06-21       Impact factor: 4.562

8.  Differential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.

Authors:  Kristin Blacklock; Gennady M Verkhivker
Journal:  PLoS One       Date:  2013-08-19       Impact factor: 3.240

Review 9.  Molecular cochaperones: tumor growth and cancer treatment.

Authors:  Stuart K Calderwood
Journal:  Scientifica (Cairo)       Date:  2013-04-17

10.  Whey protein hydrolysate enhances HSP90 but does not alter HSP60 and HSP25 in skeletal muscle of rats.

Authors:  Carolina Soares Moura; Pablo Christiano Barboza Lollo; Priscila Neder Morato; Luciana Hisayama Nisishima; Everardo Magalhães Carneiro; Jaime Amaya-Farfan
Journal:  PLoS One       Date:  2014-01-20       Impact factor: 3.240
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