Literature DB >> 12502967

The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a review.

Laura W Lamps1, Andrew L Folpe.   

Abstract

Hepatocyte paraffin-1 (HepPar-1) is a recently developed monoclonal antibody that appears to identify an antigen unique to hepatocellular mitochondria. This article reviews the use of this new antibody in the differential diagnosis of primary hepatocellular neoplasms, cholangiocarcinomas, and carcinomas metastatic to the liver. Hepatocyte paraffin-1 appears to be the most sensitive and specific positive marker of hepatocellular differentiation, but like any immunohistochemical marker, should be interpreted only in the context of the overall clinicopathologic picture and as part of a panel of antibodies.

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Year:  2003        PMID： 12502967     DOI： 10.1097/00125480-200301000-00004

Source DB:  PubMed          Journal:  Adv Anat Pathol        ISSN： 1072-4109            Impact factor:   3.875


  8 in total

Review 1.  Cervical lymph node metastases from remote primary tumor sites.

Authors:  Fernando López; Juan P Rodrigo; Carl E Silver; Missak Haigentz; Justin A Bishop; Primož Strojan; Dana M Hartl; Patrick J Bradley; William M Mendenhall; Carlos Suárez; Robert P Takes; Marc Hamoir; K Thomas Robbins; Ashok R Shaha; Jochen A Werner; Alessandra Rinaldo; Alfio Ferlito
Journal:  Head Neck       Date:  2015-12-29       Impact factor: 3.147

2.  Elevated hepatocyte paraffin 1 and neprilysin expression in hepatocellular carcinoma are correlated with longer survival.

Authors:  David Mondada; Fredrik T Bosman; Charlotte Fontolliet; Walter K F Seelentag
Journal:  Virchows Arch       Date:  2005-10-12       Impact factor: 4.064

3.  Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report.

Authors:  Chin-Ying Chien; Cheng-Cheng Hwang; Chun-Nan Yeh; Huang-Yang Chen; Jui-Teng Wu; Chan-Siu Cheung; Chih-Lang Lin; Cho-Li Yen; Wen-Yen Wang; Kun-Chun Chiang
Journal:  World J Surg Oncol       Date:  2012-01-26       Impact factor: 2.754

4.  Correlation of SOCS-1 gene with onset and prognosis of breast cancer.

Authors:  Yuetao Lv; Ge Song; Peng Li
Journal:  Oncol Lett       Date:  2018-05-09       Impact factor: 2.967

5.  New Labyrinth Microfluidic Device Detects Circulating Tumor Cells Expressing Cancer Stem Cell Marker and Circulating Tumor Microemboli in Hepatocellular Carcinoma.

Authors:  Shanshan Wan; Tae Hyun Kim; Kaylee J Smith; Ryan Delaney; G-Su Park; Hui Guo; Eric Lin; Thomas Plegue; Ning Kuo; John Steffes; Christopher Leu; Diane M Simeone; Nataliya Razimulava; Neehar D Parikh; Sunitha Nagrath; Theodore H Welling
Journal:  Sci Rep       Date:  2019-12-09       Impact factor: 4.996

Review 6.  The Significance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma: Real-Time Monitoring and Moving Targets for Cancer Therapy.

Authors:  Feiyu Chen; Zhangfeng Zhong; Hor-Yue Tan; Ning Wang; Yibin Feng
Journal:  Cancers (Basel)       Date:  2020-06-29       Impact factor: 6.639

7.  The diagnostic value of arginase-1 immunostaining in differentiating hepatocellular carcinoma from metastatic carcinoma and cholangiocarcinoma as compared to HepPar-1.

Authors:  Nehal A Radwan; Naglaa S Ahmed
Journal:  Diagn Pathol       Date:  2012-10-30       Impact factor: 2.644

8.  Subclassification and Detection of New Markers for the Discrimination of Primary Liver Tumors by Gene Expression Analysis Using Oligonucleotide Arrays.

Authors:  Holger G Hass; Ulrich Vogel; Michael Scheurlen; Jürgen Jobst
Journal:  Gut Liver       Date:  2018-05-15       Impact factor: 4.519
  8 in total

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