Literature DB >> 12502514

The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome.

Frances A Brook1, Edward P Evans, Christopher J Lord, Paul A Lyons, Daniel B Rainbow, Sarah K Howlett, Linda S Wicker, John A Todd, Richard L Gardner.   

Abstract

It would be extremely advantageous to the analysis of disease mechanisms in the spontaneous mouse model of type 1 diabetes, the nonobese diabetic (NOD) strain, if genes in this strain could be modified in vivo using embryonic stem (ES) cells and homologous recombination. However, a NOD ES cell line with adequate germline transmission has not yet been reported. We report the development of highly germline-competent ES cell lines from the F1 hybrid of NOD and 129 for use in NOD gene targeting. Consequently, we developed ES cell lines derived from (NOD x 129)F1 x 129 backcross 1 mice, which were intercrossed to select for homozygosity of particular regions of NOD genome known to contain disease loci.

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Year:  2003        PMID： 12502514     DOI： 10.2337/diabetes.52.1.205

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  18 in total

1.  Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos.

Authors:  Paul J Tesar
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-25       Impact factor: 11.205

2.  Successful derivation of EGFP-transgenic embryonic stem cell line from a genetically non-permissive FVB/N mouse.

Authors:  Gurbind Singh; Tulasigeri M Totiger; Polani B Seshagiri
Journal:  Am J Stem Cells       Date:  2012-06-03

Review 3.  Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes.

Authors:  John P Driver; Yi-Guang Chen; Clayton E Mathews
Journal:  Rev Diabet Stud       Date:  2012-12-28

Review 4.  Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.

Authors:  Nick Holmes; Anne Cooke
Journal:  Rev Diabet Stud       Date:  2012-12-28

5.  Isolation of epiblast stem cells from preimplantation mouse embryos.

Authors:  Fadi J Najm; Josh G Chenoweth; Philip D Anderson; Joseph H Nadeau; Raymond W Redline; Ronald D G McKay; Paul J Tesar
Journal:  Cell Stem Cell       Date:  2011-03-04       Impact factor: 24.633

6.  "Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells.

Authors:  Jing Chen; Peter C Reifsnyder; Felix Scheuplein; William H Schott; Maria Mileikovsky; Sharon Soodeen-Karamath; Andras Nagy; Michael H Dosch; James Ellis; Friedrich Koch-Nolte; Edward H Leiter
Journal:  Mamm Genome       Date:  2005-10-29       Impact factor: 2.957

7.  NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.

Authors:  Edward H Leiter; Peter C Reifsnyder; Racheal Wallace; Renhua Li; Benjamin King; Gary C Churchill
Journal:  Diabetes       Date:  2009-03-31       Impact factor: 9.461

8.  Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation.

Authors:  Philip D Anderson; Vicki R Nelson; Paul J Tesar; Joseph H Nadeau
Journal:  Cancer Res       Date:  2009-11-24       Impact factor: 12.701

9.  Validated germline-competent embryonic stem cell lines from nonobese diabetic mice.

Authors:  Jennifer Nichols; Kenneth Jones; Jenny M Phillips; Stephen A Newland; Mila Roode; William Mansfield; Austin Smith; Anne Cooke
Journal:  Nat Med       Date:  2009-06-02       Impact factor: 53.440

10.  Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer's disease.

Authors:  Satoshi Yamamoto; Yuki Ooshima; Mitsugu Nakata; Takashi Yano; Kunio Matsuoka; Sayuri Watanabe; Ryouta Maeda; Hideki Takahashi; Michiyasu Takeyama; Yoshio Matsumoto; Tadatoshi Hashimoto
Journal:  Transgenic Res       Date:  2012-09-09       Impact factor: 2.788
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