Literature DB >> 12502390

Inhibitory activity of corn-derived bisamide compounds against alpha-glucosidase.

Toshio Niwa1, Umeyuki Doi, Toshihiko Osawa.   

Abstract

Bioassay guided fractionation from corn gluten meal, a byproduct of a starch manufacturing plant, gave N-p-coumaroyl-N'-feruloylputrescine (1) and N,N'-diferuloylputrescine (2) as alpha-glucosidase inhibitors. Some structure-activity relationships were studied by comparing the inhibitory activity by preparing some related compounds, and it was revealed that the hydroxyl group was important for the inhibitory activity of bisamide alkaloids, but not the redox potential.

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Year:  2003        PMID： 12502390     DOI： 10.1021/jf020758x

Source DB:  PubMed          Journal:  J Agric Food Chem        ISSN： 0021-8561            Impact factor:   5.279


  7 in total

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5.  Synthesis of N-Substituted Iminosugar C-Glycosides and Evaluation as Promising α-Glucosidase Inhibitors.

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7.  α-Glucosidase inhibitory effect and simultaneous quantification of three major flavonoid glycosides in Microctis folium.

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  7 in total

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