| Literature DB >> 12502369 |
Gary B Evans1, Richard H Furneaux, Graeme J Gainsford, John C Hanson, Gregory A Kicska, Antony A Sauve, Vern L Schramm, Peter C Tyler.
Abstract
The 8-aza-immucillins (8-aza-9-deazapurines linked from C9 to C1 of 1,4-dideoxy-1,4-iminoribitol) have been designed as transition-state analogues of the reactions catalyzed by purine nucleoside phosphorylase and nucleoside hydrolases. Syntheses of the 8-aza-immucillin analogues of inosine and adenosine are described. They are powerful inhibitors of the target enzymes with equilibrium dissociation constants as low as 42 pM.Entities:
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Year: 2003 PMID： 12502369 DOI： 10.1021/jm0203332
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446