Literature DB >> 12502316

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens.

George R Pettit1, John C Knight, Delbert L Herald, Richard Davenport, Robin K Pettit, Bruce E Tucker, Jean M Schmidt.   

Abstract

Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI(50) microg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

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Year:  2002        PMID： 12502316     DOI： 10.1021/np020173x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  5 in total

1.  Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides.

Authors:  Don D Nguyen; Alexey V Melnik; Nobuhiro Koyama; Xiaowen Lu; Michelle Schorn; Jinshu Fang; Kristen Aguinaldo; Tommie L Lincecum; Maarten G K Ghequire; Victor J Carrion; Tina L Cheng; Brendan M Duggan; Jacob G Malone; Tim H Mauchline; Laura M Sanchez; A Marm Kilpatrick; Jos M Raaijmakers; René De Mot; Bradley S Moore; Marnix H Medema; Pieter C Dorrestein
Journal:  Nat Microbiol       Date:  2016-10-31       Impact factor: 17.745

2.  Pseudomonas Virulence Factor Pathway Synthesizes Autoinducers That Regulate the Secretome of a Pathogen.

Authors:  Ashley M Kretsch; Gina L Morgan; Katie A Acken; Sarah A Barr; Bo Li
Journal:  ACS Chem Biol       Date:  2021-02-17       Impact factor: 5.100

3.  Indole-fused benzooxazepines: a new structural class of anticancer agents.

Authors:  Ashok K Singh; Vinit Raj; Amit Rai; Amit K Keshari; Sudipta Saha
Journal:  Future Sci OA       Date:  2017-01-04

4.  Labradorins with Antibacterial Activity Produced by Pseudomonas sp.

Authors:  Anders Broberg; Joakim Bjerketorp; Pierre Andersson; Christer Sahlberg; Jolanta J Levenfors
Journal:  Molecules       Date:  2017-06-27       Impact factor: 4.411

5.  Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

Authors:  Florian Grundmann; Veronika Dill; Andrea Dowling; Aunchalee Thanwisai; Edna Bode; Narisara Chantratita; Richard Ffrench-Constant; Helge B Bode
Journal:  Beilstein J Org Chem       Date:  2012-05-18       Impact factor: 2.883
  5 in total

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