Literature DB >> 12502314

Araguspongines K and L, new bioactive bis-1-oxaquinolizidine N-oxide alkaloids from Red Sea specimens of Xestospongia exigua.

Khaled Y Orabi1, Khalid A El Sayed, Mark T Hamann, D Chuck Dunbar, Mansour S Al-Said, Tatsuo Higa, Michelle Kelly.   

Abstract

In addition to the previously reported (+)-araguspongine A, (+)-araguspongine C, (+)-araguspongine D, (-)-araguspongine E, and (+)-xestospongin B, two new N-oxide araguspongines, (+)-araguspongine K and (+)-araguspongine L, are described here. Their structures were established on the basis of spectral analyses including (1)H-(15)N HMBC. The promising in vitro antimalarial and antituberculosis activities of araguspongine C are reported.

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Year:  2002        PMID： 12502314      PMCID： PMC4969009          DOI： 10.1021/np0202226

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Naturally occurring somatostatin and vasoactive intestinal peptide inhibitors. Isolation of alkaloids from two marine sponges.

Authors:  A Vassas; G Bourdy; J J Paillard; J Lavayre; M Païs; J C Quirion; C Debitus
Journal:  Planta Med       Date:  1996-02       Impact factor: 3.352

2.  (+)-7S-Hydroxyxestospongin A from the marine sponge Xestospongia sp. and absolute configuration of (+)-xestospongin D.

Authors:  Surk-Sik Moon; John B MacMillan; Marilyn M Olmstead; Tram Anh Ta; Isaac N Pessah; Tadeusz F Molinski
Journal:  J Nat Prod       Date:  2002-03       Impact factor: 4.050

3.  Rapid, low-technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay.

Authors:  S G Franzblau; R S Witzig; J C McLaughlin; P Torres; G Madico; A Hernandez; M T Degnan; M B Cook; V K Quenzer; R M Ferguson; R H Gilman
Journal:  J Clin Microbiol       Date:  1998-02       Impact factor: 5.948

4.  Araguspongines B, C, D, E, F, G, H, and J, new vasodilative bis-1-oxaquinolizidine alkaloids from an okinawan marine sponge, Xestospongia sp.

Authors:  M Kobayashi; K Kawazoe; I Kitagawa
Journal:  Chem Pharm Bull (Tokyo)       Date:  1989-06       Impact factor: 1.645

5.  Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps.

Authors:  P De Smet; J B Parys; G Callewaert; A F Weidema; E Hill; H De Smedt; C Erneux; V Sorrentino; L Missiaen
Journal:  Cell Calcium       Date:  1999 Jul-Aug       Impact factor: 6.817

6.  Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor.

Authors:  J Gafni; J A Munsch; T H Lam; M C Catlin; L G Costa; T F Molinski; I N Pessah
Journal:  Neuron       Date:  1997-09       Impact factor: 17.173

7.  Marine biomolecules inhibit rat brain nitric oxide synthase activity.

Authors:  J Venkateswara Rao; D Desaiah; P J Vig; Y Venkateswarlu
Journal:  Toxicology       Date:  1998-08-21       Impact factor: 4.221
  7 in total
  6 in total

1.  Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge Neopetrosia sp.

Authors:  Dongdong Wang; Wei Jiang; Chang-Kwon Kim; Heidi R Bokesch; Girma M Woldemichael; Berkley E Gryder; John F Shern; Javed Khan; Barry R O'Keefe; John A Beutler; Kirk R Gustafson
Journal:  Org Lett       Date:  2021-04-13       Impact factor: 6.072

2.  Araguspongine C induces autophagic death in breast cancer cells through suppression of c-Met and HER2 receptor tyrosine kinase signaling.

Authors:  Mohamed R Akl; Nehad M Ayoub; Hassan Y Ebrahim; Mohamed M Mohyeldin; Khaled Y Orabi; Ahmed I Foudah; Khalid A El Sayed
Journal:  Mar Drugs       Date:  2015-01-08       Impact factor: 5.118

Review 3.  Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity.

Authors:  Hanan I Althagbi; Walied M Alarif; Khalid O Al-Footy; Ahmed Abdel-Lateff
Journal:  Mar Drugs       Date:  2020-07-17       Impact factor: 5.118

4.  Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells.

Authors:  Pablo Cruz; Ulises Ahumada-Castro; Galdo Bustos; Jordi Molgó; Daniela Sauma; Alenka Lovy; César Cárdenas
Journal:  Int J Mol Sci       Date:  2021-01-11       Impact factor: 5.923

5.  Discovery of Novel Antiangiogenic Marine Natural Product Scaffolds.

Authors:  Hassan Y Ebrahim; Khalid A El Sayed
Journal:  Mar Drugs       Date:  2016-03-11       Impact factor: 5.118

Review 6.  Natural Products Repertoire of the Red Sea.

Authors:  Ebaa M El-Hossary; Mohammad Abdel-Halim; Eslam S Ibrahim; Sheila Marie Pimentel-Elardo; Justin R Nodwell; Heba Handoussa; Miada F Abdelwahab; Ulrike Holzgrabe; Usama Ramadan Abdelmohsen
Journal:  Mar Drugs       Date:  2020-09-04       Impact factor: 5.118
  6 in total

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