Literature DB >> 1250223

Chloral hydrate mediated inhibition of cell division and of proton synthesis.

D McMahon, G Göpel.   

Abstract

Chloral hydrate (along with other anaesthetics and hypnotics) is an inhibitor of cell division. We have shown that chloral hydrate is also an inhibitor of protein synthesis. This inhibition is unlikely to be a result of either of the disruption of cell division or of interference with the function of microtubules. The ability of chloral hydrate to inhibit cell division may result from its ability to inhibit protein synthesis.

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Year:  1976        PMID: 1250223     DOI: 10.1007/bf01731678

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN: 0300-8177            Impact factor:   3.396


  16 in total

1.  A theory of gaseous anesthetics.

Authors:  S L MILLER
Journal:  Proc Natl Acad Sci U S A       Date:  1961-09-15       Impact factor: 11.205

2.  The anaphase movement of chromosomes in the spermatocytes of the grasshopper.

Authors:  H RIS
Journal:  Biol Bull       Date:  1949-02       Impact factor: 1.818

3.  Comparative study of the effects of chloral hydrate and trichloroethanol on cerebral metabolism.

Authors:  J Krieglstein; R Stock
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

4.  The effects of canavanine and of arginine starvation on macromolecular synthesis in Chlamydomonas reinhardi.

Authors:  D McMahon; P Langstroth
Journal:  J Gen Microbiol       Date:  1972-11

5.  Fine structural studies of apolar mitosis.

Authors:  J Molè-Bajer
Journal:  Chromosoma       Date:  1969       Impact factor: 4.316

6.  The anaesthetic pressures of certain fluorine-containing gases.

Authors:  K W Miller; W D Paton; E B Smith
Journal:  Br J Anaesth       Date:  1967-12       Impact factor: 9.166

7.  Chloral hydrate inhibits protein synthesis in vivo.

Authors:  D McMahon; W Blaschko
Journal:  Biochim Biophys Acta       Date:  1971-05-13

8.  Periodic increases in enzyme activity in synchronized cultures of Chlamydomonas reinhardtii.

Authors:  J R Kates; R F Jones
Journal:  Biochim Biophys Acta       Date:  1967-08-22

9.  Chromosome movements in chloral hydrate treated endosperm cells in vitro.

Authors:  J Molé-Bajer
Journal:  Chromosoma       Date:  1967       Impact factor: 4.316

10.  Effect of chloral hydrate and acetaldehyde on mitochondrial preparations from sweet potato.

Authors:  W S Pierpoint; G G Laties
Journal:  Plant Physiol       Date:  1966-01       Impact factor: 8.340

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