Literature DB >> 125015

Metabolism of nitrosamines in vivo IV. Isolation of 3-hydroxy-1-nitrosopyrrolidine from rat urine after application of 1-nitrosopyrrolidine.

F W Krüger, B Bertram.   

Abstract

After i. p. application of 6 mg/30 muCi/kg 2,5- and 3,4--14C-nitrosopyrrolidine about 20% of the radioactivity is exhaled as 14-CO2 and about 7% is found in the urine. One of the urinary metabolites was identified by thin layer chromatography, combined GC/MS spectrometry and ultraviolet absorption as 3-hydroxy-1-nitrosopyrrolidine.

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Year:  1975        PMID： 125015     DOI： 10.1007/bf00304096

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  7 in total

1.  Metabolism of nitrosamines in vivo. 3. On the methylation of nucleic acids by aliphatic Di-n-alkyl-nitrosamines in vivo resueting from heta-oxidation: the formation of 7-methylguanine after application of 2-oxo-propyl-propyl-nitrosamine and methyl-propyl-nitro-samine.

Authors:  F W Krüger; B Bertram
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973-12-06

2.  [Structure of rat urinary metabolites of the carcinogen methyl-n-butyl-nitrosamine (author's transl)].

Authors:  L Blattmann; N Joswig; R Preussmann
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1974-03-14

3.  [Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].

Authors:  L Blattmann; R Preussmann
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1974-03-14

4.  Metabolism of nitrosamines in vivo. II. On the methylation of nucleic acids by aliphatic di-n-alkyl-nitrosamines in vivo, caused by beta-oxydation: the increased formation of 7-methyl-guanine after application of beta-hydroxypropyl-propyl-nitrosamine compared to that after application of di-n-propyl-nitrosamine.

Authors:  F W Krüger
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973

5.  [A new method for the colorimetric determination of nitrosamines after cleavage of the N-nitroso-group with hydrogen bromide in glacial acetic acid].

Authors:  G Eisenbrand; R Preussmann
Journal:  Arzneimittelforschung       Date:  1970-10

6.  Alkylation of rat liver RNA by cyclic N-nitrosamines in vivo.

Authors:  K Y Lee; W Lijinsky
Journal:  J Natl Cancer Inst       Date:  1966-10       Impact factor: 13.506

7.  [Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].

Authors:  F W Krüger
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1971
  7 in total
  3 in total

Review 1.  Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed.

Authors:  Yupeng Li; Stephen S Hecht
Journal:  Int J Mol Sci       Date:  2022-04-20       Impact factor: 6.208

2.  Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.

Authors:  L Blattmann
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977

3.  Metabolism of nitrosamines in vivo. V Investigation on 14CO2 exhalation, liver RNA labelling and isolation of two metabolites from urine after administration of [2, 5-14C-]dinitrosopiperazine to rats.

Authors:  F W Krüger; B Bertram; G Eisenbrand
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-02-25
  3 in total

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