Literature DB >> 125006

Epoxide hydrase activity in mouse skin eidermis.

W G Pyerin, E Hecker.   

Abstract

By fractionation of mouse epidermis a "microsomal" fraction may be obtained with a specific EH-activity at least 6-7 times higher than that of epidermis homogenates. Such enrichment allows to utilize the radioassay with 7--3H-styrene oxide as substrate which normally is too insensitive for organs with low levels of EH-activities. By the procedure developed the unambiguous demonstration of EH-activity in the epidermis of mouse skin is possible.

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Year:  1975        PMID： 125006     DOI： 10.1007/bf00284403

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  6 in total

Review 1.  Phorbolesters--the irritants and cocarcinogens of Croton Tiglium L.

Authors:  E Hecker; R Schmidt
Journal:  Fortschr Chem Org Naturst       Date:  1974

Review 2.  Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.

Authors:  F Oesch
Journal:  Xenobiotica       Date:  1973-05       Impact factor: 1.908

3.  A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide.

Authors:  E Oesch; D M Jerina; J Daly
Journal:  Biochim Biophys Acta       Date:  1971-03-10

4.  Arene oxides: a new aspect of drug metabolism.

Authors:  D M Jerina; J W Daly
Journal:  Science       Date:  1974-08-16       Impact factor: 47.728

5.  Induction, activation and inhibition of epoxide hydrase: an anomalous prevention of chlorobenzene-induced hepatotoxicity by an inhibitor of epoxide hydrase.

Authors:  F Oesch; D M Jerina; J W Daly; J M Rice
Journal:  Chem Biol Interact       Date:  1973-03       Impact factor: 5.192

6.  Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12-dimethylbenz(a)anthracene-produced skin tumorigenesis in the mouse.

Authors:  D W Nebert; W F Benedict; J E Gielen; F Oesch; J W Daly
Journal:  Mol Pharmacol       Date:  1972-05       Impact factor: 4.436
  6 in total
  1 in total

1.  On the biochemical mechanism of tumorigenesis in mouse skin. VIII. Isolation and characterization of epidermal microsomes and properties of their arylhydrocarbon monooxygenase and epoxide hydr(at)ase.

Authors:  W G Pyerin; E Hecker
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-12-15
  1 in total

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