Literature DB >> 12499608

Chemical modification of coumarin dimer and HIV-1 integrase inhibitory activity.

Pili Chih-Min Mao1, Jean-Francois Mouscadet, Herve Leh, Christian Auclair, Ling-Yih Hsu.   

Abstract

A systematic series of chemically modified coumarin dimmers has been synthesized and tested for their inhibitory activity against HIV-1 integrase. We observed that modified coumarin dimmers containing hydrophobic moiety on the linker display potent inhibitory activities.

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Year:  2002        PMID： 12499608     DOI： 10.1248/cpb.50.1634

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  6 in total

1.  Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors.

Authors:  Brandon Ason; Daniel J Knauss; Allison M Balke; George Merkel; Anna Marie Skalka; William S Reznikoff
Journal:  Antimicrob Agents Chemother       Date:  2005-05       Impact factor: 5.191

2.  Supramolecular allosteric cofacial porphyrin complexes.

Authors:  Christopher G Oliveri; Nathan C Gianneschi; SonBinh T Nguyen; Chad A Mirkin; Charlotte L Stern; Zdzislaw Wawrzak; Maren Pink
Journal:  J Am Chem Soc       Date:  2006-12-20       Impact factor: 15.419

3.  Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors.

Authors:  I Kostova; S Raleva; P Genova; R Argirova
Journal:  Bioinorg Chem Appl       Date:  2006-02-23       Impact factor: 7.778

4.  Synthesis and characterization of novel iminobenzoates with terminal pyrazine moieties.

Authors:  Mushtaq Ahmad; Zahida Perveen; Adailton J Bortoluzzi; Shahid Hameed; Muhammad R Shah; Muhammad Tariq; Ghias Ud Din; Muhammad T Jan; Muhammad Siddique; Muhammad Anwar
Journal:  Chem Cent J       Date:  2018-03-08       Impact factor: 4.215

Review 5.  Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease.

Authors:  Zhoupeng Li; Dehui Kong; Yongsheng Liu; Mingkai Li
Journal:  Genes Dis       Date:  2021-04-20

6.  Synthesis and antibacterial activities of novel 4-hydroxy-7-hydroxy- and 3-carboxycoumarin derivatives.

Authors:  Pen-Yuan Lin; Kuang-Sheng Yeh; Chien-Ling Su; Shiow-Yunn Sheu; Tiffany Chen; Keng-Liang Ou; Mei-Hsiang Lin; Lin-Wen Lee
Journal:  Molecules       Date:  2012-09-10       Impact factor: 4.411
  6 in total

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