Literature DB >> 12499232

Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants.

Miyuki Kumano1, Masaya Fujita, Kouji Nakamura, Makiko Murata, Reiko Ohki, Kunio Yamane.   

Abstract

We isolated 19 lincomycin-resistant Bacillus subtilis mutants by expressing lmrB encoding a putative multidrug efflux protein. Eighteen of the mutants altered at two regions (-3 to -1 and +15) immediately downstream of the -10 region of the lmr promoter increased lmr transcription in vivo and in vitro.

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Year:  2003        PMID： 12499232      PMCID： PMC148993          DOI： 10.1128/AAC.47.1.432-435.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

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Authors:  O Lomovskaya; K Lewis; A Matin
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490
  10 in total
  10 in total

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Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

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Review 7.  Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.

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8.  Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus.

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9.  The putative drug efflux systems of the Bacillus cereus group.

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  10 in total

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