Literature DB >> 12499220

Site-specific mutagenesis analysis of PBP 1A from a penicillin-cephalosporin-resistant pneumococcal isolate.

Anthony M Smith1, Keith P Klugman.   

Abstract

Our mutagenesis study has investigated all amino acid mutations in the penicillin-binding domain of PBP 1A from Hungarian pneumococcal isolate 3191 to determine the importance of every mutation in the development of penicillin and cefotaxime resistance. Our data reveal that mutations at amino acid positions 574 to 577 and position 539 cause penicillin and cefotaxime resistance.

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Year:  2003        PMID： 12499220      PMCID： PMC149026          DOI： 10.1128/AAC.47.1.387-389.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  Adaptation to the environment: Streptococcus pneumoniae, a paradigm for recombination-mediated genetic plasticity?

Authors:  J P Claverys; M Prudhomme; I Mortier-Barrière; B Martin
Journal:  Mol Microbiol       Date:  2000-01       Impact factor: 3.501

2.  Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae.

Authors:  R Muñoz; C G Dowson; M Daniels; T J Coffey; C Martin; R Hakenbeck; B G Spratt
Journal:  Mol Microbiol       Date:  1992-09       Impact factor: 3.501

3.  Non-Penicillin-Binding protein mediated high-level penicillin and cephalosporin resistance in a Hungarian clone of Streptococcus pneumoniae.

Authors:  A M Smith; K P Klugman
Journal:  Microb Drug Resist       Date:  2000       Impact factor: 3.431

4.  Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics.

Authors:  N Mouz; A M Di Guilmi; E Gordon; R Hakenbeck; O Dideberg; T Vernet
Journal:  J Biol Chem       Date:  1999-07-02       Impact factor: 5.157

5.  Alterations in MurM, a cell wall muropeptide branching enzyme, increase high-level penicillin and cephalosporin resistance in Streptococcus pneumoniae.

Authors:  A M Smith; K P Klugman
Journal:  Antimicrob Agents Chemother       Date:  2001-08       Impact factor: 5.191

6.  Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding proteins 1a and 1b.

Authors:  C Martin; T Briese; R Hakenbeck
Journal:  J Bacteriol       Date:  1992-07       Impact factor: 3.490

7.  The fib locus in Streptococcus pneumoniae is required for peptidoglycan crosslinking and PBP-mediated beta-lactam resistance.

Authors:  B Weber; K Ehlert; A Diehl; P Reichmann; H Labischinski; R Hakenbeck
Journal:  FEMS Microbiol Lett       Date:  2000-07-01       Impact factor: 2.742

8.  Penicillin-binding proteins of multiply antibiotic-resistant South African strains of Streptococcus pneumoniae.

Authors:  S Zighelboim; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1980-03       Impact factor: 5.191

9.  Penicillin-binding proteins of penicillin-susceptible and -resistant pneumococci: immunological relatedness of altered proteins and changes in peptides carrying the beta-lactam binding site.

Authors:  R Hakenbeck; H Ellerbrok; T Briese; S Handwerger; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1986-10       Impact factor: 5.191

10.  Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Authors:  R Hakenbeck; M Tarpay; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1980-03       Impact factor: 5.191
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  10 in total

1.  An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci.

Authors:  Christoph Hauser; Suzanne Aebi; Kathrin Mühlemann
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

2.  Active site restructuring regulates ligand recognition in class A penicillin-binding proteins.

Authors:  Pauline Macheboeuf; Anne Marie Di Guilmi; Viviana Job; Thierry Vernet; Otto Dideberg; Andréa Dessen
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-06       Impact factor: 11.205

3.  Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance.

Authors:  Laurent Chesnel; Raphaël Carapito; Jacques Croizé; Otto Dideberg; Thierry Vernet; André Zapun
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

4.  Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan.

Authors:  Yumiko Sanbongi; Takashi Ida; Midori Ishikawa; Yumi Osaki; Hiroshi Kataoka; Takahisa Suzuki; Kumiko Kondo; Fukuichi Ohsawa; Minoru Yonezawa
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

5.  Crystal structures of bifunctional penicillin-binding protein 4 from Listeria monocytogenes.

Authors:  Jae-Hee Jeong; Yi-Seul Kim; Catleya Rojviriya; Sung-Chul Ha; Beom Sik Kang; Yeon-Gil Kim
Journal:  Antimicrob Agents Chemother       Date:  2013-05-13       Impact factor: 5.191

6.  Whole Genome Sequencing of 39 Invasive Streptococcus pneumoniae Sequence Type 199 Isolates Revealed Switches from Serotype 19A to 15B.

Authors:  Oliwia Makarewicz; Marie Lucas; Christian Brandt; Leonie Herrmann; Andreas Albersmeier; Christian Rückert; Jochen Blom; Alexander Goesmann; Mark van der Linden; Jörn Kalinowski; Mathias W Pletz
Journal:  PLoS One       Date:  2017-01-03       Impact factor: 3.240

7.  Long Persistence of a Streptococcus pneumoniae 23F Clone in a Cystic Fibrosis Patient.

Authors:  Martin Rieger; Harald Mauch; Regine Hakenbeck
Journal:  mSphere       Date:  2017-06-07       Impact factor: 4.389

8.  New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary.

Authors:  Inga Schweizer; Sebastian Blättner; Patrick Maurer; Katharina Peters; Daniela Vollmer; Waldemar Vollmer; Regine Hakenbeck; Dalia Denapaite
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

9.  The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins.

Authors:  Ricardo Dias; David Félix; Manuela Caniça; Marie-Claude Trombe
Journal:  BMC Microbiol       Date:  2009-06-05       Impact factor: 3.605

10.  Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.

Authors:  Claire Chewapreecha; Pekka Marttinen; Nicholas J Croucher; Susannah J Salter; Simon R Harris; Alison E Mather; William P Hanage; David Goldblatt; Francois H Nosten; Claudia Turner; Paul Turner; Stephen D Bentley; Julian Parkhill
Journal:  PLoS Genet       Date:  2014-08-07       Impact factor: 5.917
  10 in total

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