Rat testicular structure and ultrastructure after paracetamol treatment.

The morphological modifications of Wistar rat testicles were investigated for animals treated with paracetamol. The rats (n = 6) received a single dose of 4.4 mmol/kg paracetamol, while controls (n = 6) received the same volume of physiological solution. After 5, 10 and 50 days, the rats were perfused with Karnovsky's fixative and processed by routine methods for light and electron microscopy. Some altered seminiferous tubules were found, as well as a few degenerating tubules. Within the tubules, Sertoli cells appeared fragmented while the spermatids showed unusually well-developed rough endoplasmic reticulum and Golgi complexes and had irregularly compacted chromatin. Morphologically altered late spermatids were found retaining a larger volume of residual cytoplasm than spermatids of controls. An indirect cause of alterations was also suggested based on the occurrence of dilated blood vessels and edema. Copyright 2002 Elsevier Science Inc.