Literature DB >> 12498878

Combinatorial glycosylation of glycopeptide antibiotics.

Richard H Baltz1.   

Abstract

The glycosyltransferases GtfE and GtfD from the vancomycin producer Amycolatopsis orientalis have promiscuous substrate and NDP-sugar specificities. They have been used to generate novel glycopeptide antibiotics containing the heptapeptide scaffolds of vancomycin and teichoplanin.

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Year:  2002        PMID: 12498878     DOI: 10.1016/s1074-5521(02)00289-2

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  1 in total

1.  Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase.

Authors:  Jian Liu; Chuanyun Luo; Peter A Smith; Jodie K Chin; Malcolm G P Page; Mark Paetzel; Floyd E Romesberg
Journal:  J Am Chem Soc       Date:  2011-10-14       Impact factor: 15.419

  1 in total

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