Literature DB >> 12498706

RNA interference: the fragile X syndrome connection.

Richard W Carthew1.   

Abstract

Fragile X syndrome is caused by loss of expression of FMRP, a protein proposed to act as a regulator of mRNA translation which promotes synaptic maturation and function. Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi.

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Year:  2002        PMID： 12498706     DOI： 10.1016/s0960-9822(02)01352-0

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  7 in total

1.  Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs.

Authors:  Samuel Solomon; Yaoxian Xu; Bin Wang; Muriel D David; Peter Schubert; Derek Kennedy; John W Schrader
Journal:  Mol Cell Biol       Date:  2007-01-08       Impact factor: 4.272

2.  Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs.

Authors:  Oliver Rackham; Chris M Brown
Journal:  EMBO J       Date:  2004-07-29       Impact factor: 11.598

3.  Expression patterns of microRNAs associated with CML phases and their disease related targets.

Authors:  Kateřina Machová Poláková; Tereza Lopotová; Hana Klamová; Pavel Burda; Marek Trněný; Tomáš Stopka; Jana Moravcová
Journal:  Mol Cancer       Date:  2011-04-18       Impact factor: 27.401

4.  siRNA target site secondary structure predictions using local stable substructures.

Authors:  Bret S E Heale; Harris S Soifer; Chauncey Bowers; John J Rossi
Journal:  Nucleic Acids Res       Date:  2005-02-18       Impact factor: 16.971

Review 5.  The role of small RNAs in human diseases: potential troublemaker and therapeutic tools.

Authors:  Huan Gong; Chang-Mei Liu; De-Pei Liu; Chih-Chuan Liang
Journal:  Med Res Rev       Date:  2005-05       Impact factor: 12.944

Review 6.  The therapeutic potential of RNA interference.

Authors:  Susan L Uprichard
Journal:  FEBS Lett       Date:  2005-08-15       Impact factor: 4.124

7.  Normal RNAi response in human fragile x fibroblasts.

Authors:  Charlotte Madsen; Karen Grønskov; Karen Brøndum-Nielsen; Thomas G Jensen
Journal:  BMC Res Notes       Date:  2009-09-09
  7 in total

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