Literature DB >> 12498018

FR-901228 Fujisawa/National Cancer Institute.

David M Vigushin1.   

Abstract

The depsipeptide FR-901228 is a histone deacetylas inhibitor under development by Fujisawa and the National Cancer Institute as a potential treatment for neoplasm. By May 2002, phase II trials had commenced in the US [452248], [461017].

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Year:  2002        PMID： 12498018

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  6 in total

1.  Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro.

Authors:  Yiya Yang; Kanghan Liu; Yumei Liang; Yinyin Chen; Ying Chen; Yuting Gong
Journal:  Int J Clin Exp Pathol       Date:  2015-03-01

2.  Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum No. 968.

Authors:  Yi-Qiang Cheng; Min Yang; Andrea M Matter
Journal:  Appl Environ Microbiol       Date:  2007-03-30       Impact factor: 4.792

Review 3.  Reactive oxygen species-mediated therapeutic control of bladder cancer.

Authors:  Hwa-Chain R Wang; Shambhunath Choudhary
Journal:  Nat Rev Urol       Date:  2011-10-04       Impact factor: 14.432

4.  Pro-apoptotic activity of oncogenic H-Ras for histone deacetylase inhibitor to induce apoptosis of human cancer HT29 cells.

Authors:  Shambhunath Choudhary; Hwa-Chain Robert Wang
Journal:  J Cancer Res Clin Oncol       Date:  2007-05-04       Impact factor: 4.553

5.  Role of reactive oxygen species in proapoptotic ability of oncogenic H-Ras to increase human bladder cancer cell susceptibility to histone deacetylase inhibitor for caspase induction.

Authors:  Shambhunath Choudhary; Hwa-Chain Robert Wang
Journal:  J Cancer Res Clin Oncol       Date:  2009-06-09       Impact factor: 4.553

6.  Treating Colon Cancer Cells with FK228 Reveals a Link between Histone Lysine Acetylation and Extensive Changes in the Cellular Proteome.

Authors:  Tian-yun Wang; Yan-long Jia; Xi Zhang; Qiu-li Sun; Yi-chun Li; Jun-he Zhang; Chun-peng Zhao; Xiao-yin Wang; Li Wang
Journal:  Sci Rep       Date:  2015-12-17       Impact factor: 4.379
  6 in total

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